International Journal of Hypertension / 2015 / Article / Tab 2

Research Article

Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West Africa

Table 2

Frequencies of renin-angiotensin system genes polymorphisms (cases versus controls).

PolymorphismsControlsCasesOR95% CI value

Total204202
AGT 235M/T
 TT versus MT + MM, (%)177 (86.76)171 (84.65)0.840.46–1.530.57
 MT versus TT + MM, (%)24 (11.77)29 (14.36)1.260.68–2.350.46
 MM versus TT + MT, (%)3 (1.47)2 (0.99)0.670.06–5.921
 T versus M, (%)378 (0.93)371 (0.92)0.890.51–1.540.70
 HWE value0.150.83
ACE I/D
 DD versus ID + II, (%)73 (35.78)135 (66.83)3.622.35–5.56<0.00001
 ID versus II + DD, (%)104 (50.98)57 (28.22)0.380.25–0.58<0.00001
 II versus DD + ID, (%)27 (13.24)10 (4.95)0.340.14–0.760.005
 D versus I, (%)250 (0.61)327 (0.81)2.681.93–3.74<0.00001
 HWE value0.570.48
AT1R 1166 A/C
 CC versus AC + AA, (%)0 (0.00)0 (0.00)00–4.210.19
 AC versus AA + CC, (%)7 (3.43)7 (3.47)1.010.30–3.441.00
 AA versus CC + AC, (%)197 (96.57)195 (96.53)0.990.29–3.381.00
 C versus A, (%)7 (0.02)7 (0.02)1.010.30–3.411.00
 HWE value0.970.97

OR: odds ratio; CI: confidence intervals; HWE: Hardy-Weinberg equilibrium; AGT: angiotensinogen; ACE: angiotensin converting enzyme; AT1R: angiotensin II type 1 receptor.

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