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International Journal of Hypertension
Volume 2016 (2016), Article ID 2402515, 8 pages
http://dx.doi.org/10.1155/2016/2402515
Research Article

The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis

1Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, FL, USA
2Internal Medicine Department, Mercy Medical Center, Clinton, IA, USA

Received 18 February 2016; Accepted 6 June 2016

Academic Editor: Markus P. Schlaich

Copyright © 2016 Mehdi Mirsaeidi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. The association between the level of systemic inflammation and systemic hypertension (sHTN) among subjects with sarcoidosis has not been previously explored. Methods. A retrospective study was conducted to investigate the relation between the level of systemic inflammation in sarcoidosis, measured by various serum inflammatory markers, and sHTN. Results. Among a total of 108 cases with sarcoidosis (mean age: 53.4 years, 76.9% females), 55 (50.9%) had sHTN and 53 (49.1%) were normotensive. ESR was highly associated with sHTN. The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; ). ROC curve analysis for ESR revealed an AUC value of 0.795 (95% CI: 0.692–0.897; ). With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; ) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; ). ROC curve analysis for CRP revealed an AUC value of 0.644 (95% CI: 0.518–0.769; ). On multivariate analysis, ESR and the CRP remained independent predictors for sHTN among subjects with sarcoidosis. Conclusion. Systemic inflammation is associated with the presence of sHTN in sarcoidosis.