International Journal of Hypertension / 2016 / Article / Tab 2

Research Article

The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis

Table 2

Associations between various inflammatory markers with prevalence of systemic hypertension in sarcoidosis patients.

Inflammatory markers
All subjects ()Sarcoidosis with HTN ()Sarcoidosis without HTN () value

Erythrocyte sedimentation rate
ESR (mm/hr, mean ± SD)35.2 ± 33.448.8 ± 3523.2 ± 270.001
ESR (mm/hr, median, IQR)25 (12.5–44)34.5 (23.8–81)13 (10–28)
ESR quartile 1 (ESR < 12.5 mm/hr), % ()24.7% (20)10% (2)90% (18)0.001
ESR quartile 2 (ESR 12.5–24 mm/hr), % ()27.2% (22)40.9% (9)59.1% (13)0.509
ESR quartile 3 (ESR 25–44 mm/hr), % ()23.5% (19)63.2% (12)36.8% (7)0.11
ESR quartile 4 (ESR > 44 mm/hr), % ()24.7% (20)75% (15)25% (5)0.006

C-reactive protein
CRP (mg/L, mean ± SD)2.5 ± 4.23.4 ± 4.51.7 ± 3.70.067
CRP (mg/L, median, IQR)1 (0.6, 2.37)1.1 (0.65, 3.65)0.9 (0.5, 1.8)
CRP > 2% ()28.9% (24)45% (18)14% (6)0.003
CRP > 2.5% ()22.9% (19)37.5% (15)9.3% (4)0.004
CRP > 3% ()20.7% (17)38.5% (15)4.7% (2)0.001
CRP > 3.5% ()14.5% (12)27.5% (11)2.3% (1)0.01
CRP quartile 1 (CRP < 0.6 mg/dL), % ()23.8% (20)30% (6)70% (14)0.059
CRP quartile 2 (CRP 0.6–0.99 mg/dL), % ()28.6% (24)58.3% (14)41.7% (10)0.272
CRP quartile 3 (CRP 1.0–2.37 mg/dL), % ()22.6% (19)26.3% (5)73.7% (14)0.031
CRP quartile 4 (CRP > 2.37 mg/dL), % ()25% (21)76.2% (16)23.8% (5)0.006

Albumin
Albumin (gm/dL, mean ± SD)3.6 ± 0.583.44 ± 0.633.77 ± 0.490.004
Albumin (gm/dL, median, IQR)3.7 (3.4–4)3.6 (3.2–3.8)3.8 (3.6–4.1)
Albumin quartile 1 (albumin < 3.4 gm/dL), % ()24% (24)70.8% (17)29.2% (7)0.017
Albumin quartile 2 (albumin 3.4–3.69 gm/dL), % ()19% (19)52.6% (10)47.4% (9)0.725
Albumin quartile 3 (albumin 3.7–4.1 gm/dL), % ()29% (29)48.3% (14)51.7% (15)0.926
Albumin quartile 4 (albumin > 4.1 gm/dL), % ()28% (28)28.6% (8)71.4% (20)0.013

Other inflammatory markers
Ferritin (ng/mL, mean ± SD)161.4 ± 602245 ± 85783 ± 910.262
ACE level (U/L, mean ± SD)63.2 ± 49.552.9 ± 5571.4 ± 43.80.121
25 OH vitamin D (g/L, mean ± SD)16.1 ± 8.515.7 ± 8.716.5 ± 8.30.657

HTN: systemic hypertension, ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, ACE: angiotensin converting enzyme, m: mean, SD: standard deviation, and IQR: interquartile range.

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