Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect

Figure 3

Duration of drinking time after intracerebroventricular (icv) administration of angiotensin (Ang) II, Ang III, or aminopeptidase A (APA). Duration of drinking time was measured after icv administration of aCSF, 25 ng of Ang II, 25 ng of Ang III, or 800 ng of APA. This dose of Ang II or Ang III evoked similar pressor response to 800 ng of APA. After icv administration of CSF, drinking behavior was not observed; after icv administration of Ang II and Ang III, continuous drinking behavior was observed; after icv administration of APA, drinking behavior was not observed. Values are expressed as mean ± SE.