Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect

Table 1

Intracerebroventricular administration of aCSF, 400 ng of aminopeptidase A (APA), and 800 ng of APA.

	Change of MAP (mmHg)	Time to achieve peak pressor response (s)	Duration of pressor response (s)
Vehicle	0.3 ± 1.3	—	—
APA 400 ng	12.6 ± 3.0	29 ± 5	263 ± 81
APA 800 ng	19.0 ± 3.1	28 ± 17	780 ± 102

Values are expressed as mean ± SE. Results were analyzed using ANOVA. versus vehicle; versus 400 ng of APA.