Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect

Table 2

Intracerebroventricular (icv) administration of 800 ng of aminopeptidase A (APA) after icv administration of vehicle or telmisartan.

Pretreatment drug	Baseline MAP change (mmHg)	MAP change after icv of APA (mmHg)	Time to achieve peak pressor response (s)	Duration of pressor response (s)
Vehicle	1.3 ± 3.2	22.1 ± 2.2	52 ± 22	662 ± 109
Telmisartan	−2.6 ± 1.9	10.4 ± 3.2	41 ± 21	486 ± 153

Values are expressed as mean ± SE. Results were analyzed using Student’s -test. versus vehicle.