Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect

Table 3

Intracerebroventricular (icv) administration of 800 ng of aminopeptidase A (APA) after icv administration of vehicle, amastatin, or HOE-140.

Pretreatment drug	Baseline MAP change (mmHg)	MAP change after icv of APA (mmHg)	Time to achieve peak pressor response (s)	Duration of pressor response (s)
Vehicle	−2.8 ± 3.2	26.5 ± 1.1	20 ± 3	399 ± 62
Amastatin	−3.6 ± 3.4	14.4 ± 4.2	47 ± 18	618 ± 121
HOE-140	−0.3 ± 1.7	16.4 ± 2.2	38 ± 9	469 ± 83

Values are expressed as mean ± SE. Results were analyzed using Student’s -test. versus vehicle.