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International Journal of Hypertension
Volume 2018 (2018), Article ID 8954718, 5 pages
Research Article

Serum Presepsin Levels Are Not Elevated in Patients with Controlled Hypertension

1Department of Cardiology, School of Medicine, Education and Research Hospital, Uşak University, Uşak, Turkey
2Department of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey
3Department of Biochemistry, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey
4Department of Internal Medicine, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey

Correspondence should be addressed to Ismail Biyik; moc.oohay@dmkiyibliamsi

Received 6 November 2017; Revised 3 January 2018; Accepted 11 January 2018; Published 8 February 2018

Academic Editor: Tomohiro Katsuya

Copyright © 2018 Ismail Biyik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Hypertension (HT) is a common serious condition associated with cardiovascular morbidity and mortality. The pathogenesis of HT is multifactorial and has been widely investigated. Besides the vascular, hormonal, and neurological factors, inflammation plays a crucial role in HT. Many inflammatory markers such as C-reactive protein, cytokines, and adhesion molecules have been studied in HT, which supported the role of inflammation in the pathogenesis of HT. Presepsin (PSP) is a novel biomarker of inflammation. Therefore, the potential relationship between PSP and HT was investigated in this study. Methods. Forty-eight patients with controlled HT and 48 controls without HT were included in our study. Besides routine clinical and laboratory data, PSP levels were measured in peripheral venous blood samples from all the participants. Results. PSP levels were significantly lower in patients with HT than in controls ( versus  pg/mL, ). PSP levels were positively correlated with hsCRP among both the patient and the control groups ( and , resp.). However, PSP levels were not correlated with WBC among both groups ( and , resp.). Conclusions. PSP levels are not elevated in patients with well-controlled HT compared to controls. This result may be associated with anti-inflammatory effects of antihypertensive medicines.