Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study

Table 3

Association between E158K in FMO3 and hypertension, stratified by current smoking status and race in the ARIC study.

	Smokers and non-smokers combined			Smokers only			Non-smokers only
	N	Odds Ratio	P-value	N	Odds Ratio	P-value	N	Odds Ratio	P-value
		(95% CI)			(95% CI)			(95% CI)
African Americans	2814	1.14 (0.94, 1.39)	0.18	794	1.42 (0.98, 2.06)	0.07	2020	1.05 (0.84, 1.32)	0.67
European Americans	7350	1.07 (0.93, 1.23)	0.35	1721	1.14 (0.83, 1.58)	0.41	5629	1.05 (0.89, 1.22)	0.58

P-value for interaction between E158K and current smoking status was 0.07 in African Americans and 0.41 in European Americans.
Covariates: age, sex, body mass index, and the first 10 race-specific principal components. The analysis is European Americans also included study center.