Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study

Table 5

Results from low-frequency single-variant analysis of FMO3 with SBP and DBP as outcomes in European Americans.

Variant	MAC	Non-coding/coding allele	Classification	SBP			DBP
				Estimate	P-value	95% CI	Estimate	P-value	95% CI
rs72549326	38	C/T	Nonsynonymous	0.59	0.83	(-4.89, 6.07)	-0.71	0.68	(-4.02, 2.61)
rs75904274	257	G/T	Nonsynonymous	2.98	0.006	(0.85, 5.11)	1.08	0.10	(-0.20, 2.37)

SBP, systolic blood pressure; DBP, diastolic blood pressure; MAC, minor allele count; CI, confidence interval.
All variants in European Americans with a MAF between 0.1% and 5% were included in this analysis.