Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study

Table 6

Gene-based tests for the association of FMO3 with SBP and DBP.

Outcome	Test	European Americans		African Americans
		Estimate	P-value	Estimate	P-value
SBP	SKAT	-	0.008	-	0.34
	Burden	1.74	0.04	-0.57	0.43
DBP	SKAT	-	0.13	-	0.66
	Burden	0.34	0.52	0.17	0.70

SBP, systolic blood pressure; DBP, diastolic blood pressure; SKAT, Sequence Kernel Association Test.
Variants with MAF < 5% were included (European Americans: 62 variants; African Americans: 41 variants).