Feasibility of Screening Primary Aldosteronism by Aldosterone-to-Direct Renin Concentration Ratio Derived from Chemiluminescent Immunoassay Measurement: Diagnostic Accuracy and Cutoff Value

Table 4

Sensitivity, specificity, positive predictive value, and negative predictive value of different cutoff values of ADRR.

criterion	sensitivity	specificity	+PV	-PV
>1.58	88.52	78.95	31.8	98.4
>2.04	81.97	85.53	38.6	97.7
>2.33	80.33	88.16	43.0	97.6
>2.93	80.33	92.11	53.1	97.7
>3.52	70.49	92.54	51.2	96.6
>4.20	67.21	95.18	60.8	96.3
>4.91	65.57	96.06	64.9	96.2

ADRR: aldosterone-to-direct renin concentration ratio; +PV: positive predictive value; -PV: negative predictive value. ADRR is expressed in (ng/dL)/(mU/L). The cutoff value in bold was used in the present study.