International Journal of Hypertension / 2019 / Article / Tab 2

Review Article

Arterial Hypertension and Interleukins: Potential Therapeutic Target or Future Diagnostic Marker?

Table 2

Anti-inflammatory effects of cardiovascular drugs.

Effects on inflammatory cytokines Antihypertensive mechanisms Proposed References

Statins IL-1NF-B inhibition
AT1R
downregulation
HMC CoA inhibition
(G protein coupled
signalling inhibition)
PPAR- inhibition
Upregulates NO
synthase
[162, 164, 166, 167, 174]
IL-6
MCP-1
ICAM-1
MMP-2
MMP-9
hs-CRP
PAI-1
NO

ARBs/ACEIs IL-1NF-B inhibition
AT1R
downregulation
Decreased ACE
synthesis
[8, 56, 164]
IL-6
TGF- (losartan)
NO (AT2R)

Calcium channel blockers MMP-2 Protein kinase pathway (MMP-2) [174, 176]
MMP-9
IL-1
IL-18
CRP
MCP-1
ICAM-1

IL: interleukin; MCP: macrophage chemotactic factor-1; ICAM-1: intercellular adhesion molecule-1; MMP: matrix metalloproteinase; NO: nitric oxide; ARBs: angiotensinogen receptor blockers; ACEIs: angiotensin converting enzyme inhibitors; NF-B: nuclear factor B; AT1R: angiotensinogen type 1 receptor; HMC CoA: hydroxy-methyl-glutaryl coenzyme A; hs-CRP: high sensitivity C reactive protein.

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