Research Article

Early- and Late-Onset Preeclampsia: A Comprehensive Cohort Study of Laboratory and Clinical Findings according to the New ISHHP Criteria

Table 4

Characteristics and occurrence of adverse maternal outcomes in women with early-onset and late-onset preeclampsia.

EOP (n = 113)LOP (n = 101)Total (n = 214)

Maternal age at EDD, years ± SD (range)30.7 ± 5.5 (19.00–48.00)30.1 ± 5.3 (19.00–47.00)30.43 ± 5.4 (19.00–48.00)ns
Gestational age at inclusion, weeks ± SD (range)30.0 ± 2.5 (22.0–33.0)36.2 ± 1.4 (34.0–39.3)33.1 ± 1.6 (22.0–39.3)0.00001
Systolic blood pressure on admission, mmHg ± SD (range)178 ± 18 (140–240)168 ± 18 (120–230)173 ± 18 (120–240)0.005
Diastolic blood pressure on admission, mmHg ± SD (range)109 ± 12 (90–150)104 ± 11 (70–145)106 ± 11 (70–150)0.026
Antihypertensive drug administration, n (%)
 Methyldopa106 (93.8)90 (90.0)196 (94.8)ns
 Calcium channel blocker46 (40.7)29 (29.0)75 (35.0)ns
 Beta-blocker65 (57.5)26 (26.0)91 (42.5)<0.001
Resistant hypertension, n (%)34 (30.0)2 (2.0)36 (16.8)<0.0001
MgSO4 administered, n (%)65 (57.5)30 (30.0)85 (45.8)<0.001
Admission-to-delivery interval, days ± SD (range)6.8 ± 6.8 (1–30)6 ± 8.5 (1–53)6 ± 7.0 (1–53)0.021
Gestational age at delivery, weeks ± SD (range)30.6 ± 2.2 (23.0–33.8)36.6 ± 1.4 (34.0–39.5)33.9 ± 1.9 (23.0–39.5)<0.0001
Delivery-to-discharge interval, days ± SD (range)6.7 ± 3.5 (3–24)6.4 ± 3.6 (3–30)6.5 ± 3 (3–30)ns
Severe preeclampsia, n (%)109 (96.4)87 (87.0)196 (91.5)0.0412
HELLP, n (%)5 (4.4)4 (4.0)9 (4.2)ns
Eclampsia before delivery, n (%)0 (0.0)2 (2.0)2 (0.9)ns
Postpartum eclampsia, n (%)17 (15.0)7 (7.0)24 (11.2)ns
Placental abruption, n (%)19 (16.8)4 (4.0)23 (10.7)0.004
Hemorrhage, n (%)3 (2.6%)1 (1.0)4 (1.8)ns
Blood transfusion, n (%)12 (10.6)7 (7.0)19 (8.8)ns
Albumin transfusion, n (%)22 (19.4)8 (8.0)30 (14.0)0.019
Anemia, n (%)50 (44.2)40 (40.0)90 (42.0)ns
Pulmonary edema, n (%)5 (4.4)0 (0.0)5 (2.3)ns
Hysterectomy, n (%)0 (0.0)1 (1.0)1 (0.4)ns
Maternal death, n (%)1 (0.8)01 (0.4)ns
DIC, n (%)0 (0.0)2 (2.0)2 (0.9)ns
ICU, n (%)22 (19.4)6 (6.0)28 (13.0)0.02
Uterine contraction disorders, n (%)3 (2.6)1 (1.0)4 (1.8)ns
Thrombosis, n (%)2 (1.7)4 (4.0)6 (2.8)ns
Healing disorders of the scar, n (%)3 (2.6)6 (6.0)9 (4.2)ns
Genitourinary infection, n (%)31 (27.4)15 (15.0)46 (21.5)0.0385

DIC, disseminated intravascular coagulation; EDD, estimated date of delivery; EOP, early-onset preeclampsia; HELLP, hemolysis, elevated liver enzymes, low platelets; ICU, intensive care unit; LOP, late-onset preeclampsia; ns, nonstatistically significant; SD, standard deviation.