Research Article

Early- and Late-Onset Preeclampsia: A Comprehensive Cohort Study of Laboratory and Clinical Findings according to the New ISHHP Criteria

Table 7

Fetal factors associated with early- and late-onset preeclampsia.

EOP (n = 113)LOP (n = 101)Total (n = 214)

Gestational age at delivery, weeks ± SD (range)30.6 ± 2.2 (23.0–33.8)36.6 ± 1.4 (34.0–39.5)33.9 ± 1.9 (23.0–39.5)<0.0001
Birth weight (g), mean ± SD (range)1358 ± 497 (460–3450)2511 ± 689 (1010–4320)1934 ± 592 (460–4320)<0.001
Fetal sex
 Female, n (%)63 (56.0)53 (52.0)116 (54.0)ns
 Male, n (%)50 (44.0)48 (48.0)98 (46.0)ns
Intrauterine fetal distress, n (%)78 (69.0)33 (33.0)111 (51.8)<0.001
UA PI >95th percentile, n (%)27 (23.9)15 (15.0)42 (19.6)ns
MCA PI <5th percentile, n (%)52 (46.0)11 (11.0)63 (29.4)<0.001
CPR <5th percentile, n (%)79 (70.0)32 (32.0)111 (51.8)0.001
FGR <10th percentile, n (%)80 (70.7)49 (49.0)129 (60.2)0.0015
FGR <5th percentile, n (%)71 (62.8)46 (46.0)117 (54.6)0.006
FGR <3rd percentile, n (%)66 (58.4)37 (37.0)103 (48.1)0.002
Apgar score at 1 min, mean ± SD (range)6.7 ± 1.9 (1–10)9.1 ± 1.4 (1–10)7.9 ± 1.5 (1–10)<0.001
Apgar score at 3 min, mean ± SD (range)7.4 ± 1.7 (1–10)9.6 ± 0.7 (7–10)8.5 ± 1.4 (1–10)<0.001
Apgar score at 5 min, mean ± SD (range)7.8 ± 1.3 (4–10)9.8 ± 0.6 (7–10)8.8 ± 1.3 (4–10)<0.001
Apgar score <7 at 1 min, n (%)51 (45.0)4 (4.0)55 (25.7)<0.001
Apgar score <7 at 3 min, n (%)27 (23.9)2 (2.0)29 (13.5)<0.001
Apgar score <7 at 5 min, n (%)19 (16.8)0 (0.0)19 (8.8)<0.001
Intrauterine fetal death, n (%)1 (0.9)0 (0.0)1 (0.4)ns
IVH, n (%)31 (27.4)1 (1.0)32 (14.9)<0.0001
FFP transfusion, n (%)15 (13.3)0 (0.0)15 (7.0)0.0002
Mechanical ventilation33 (29.2)1 (1.0)34 (15.9)<0.0001
Infection complications, n (%)
 Early sepsis18 (16.0)1 (1.0)19 (8.8)0.0004
 Late sepsis20 (17.7)2 (2.0)22 (10.2)0.0021
Retinopathy, n (%)2 (1.8)0 (0.0)2 (0.9)ns
NEC, n (%)3 (2.6)0 (0.0)3 (1.4)ns
Fetal death, n (%)13 (11.5)0 (0.0)13 (6.0)0.0008
 Born ≤28 weeks10 (8.8)0 (0.0)0.0058
 Born >28 weeks3 (2.6)0 (0.0)ns

CPR, cerebroplacental ratio; FFP, fresh frozen plasma; FGR, fetal growth restriction; IVH, intraventricular hemorrhage; MCA, middle cerebral artery; NEC, necrotizing enterocolitis; ns, nonstatistically significant; PI, pulsatility index; RDS, respiratory distress syndrome; SD, standard deviation; UA, umbilical artery; EOP, early-onset preeclampsia; LOP, late-onset preeclampsia.