Chronic NO Restriction in Hypertensive Rats Increases Abdominal but Not Thoracic Aortic Intrinsic Stiffness via an Augmentation in Profibrotic Materials

Table 1

Parameters for the model characterization.

		WKY	SHR	SHRLN
Body weight	g	432 ± 3	398 ± 12	373 ± 15
Left ventricle weight	mg/cm	32.8 ± 0.4	45.2 ± 1.3	50.4 ± 1.0#
Kidney weight	mg/cm	53.8 ± 8	54.1 ± 1.6	56.7 ± 1.7
24h proteinuria	mg/24h	0.98 ± 0.09	9.50 ± 1.12	47.3 ± 12.5#
Protein/creatinine		0.65 ± 0.01	0.69 ± 0.07	3.96 ± 1.11#
n		6	6	8

Parameters measured to characterize the model confirm previous observations: the body weight was slightly reduced in SHRLN, kidney weight was not modified but 24h proteinuria and protein/creatinine ratio were increased indicating renal dysfunction. Left ventricular hypertrophy was visible in SHR but was more pronounced in SHRLN as shown by its normalized weight. Results are expressed as mean ± SEM. significantly different (P < 0.05) compared to WKY; #significantly different (P < 0.05) compared to SHR basal. The numbers of rats (n) are indicated at the bottom of the table.