Chronic NO Restriction in Hypertensive Rats Increases Abdominal but Not Thoracic Aortic Intrinsic Stiffness via an Augmentation in Profibrotic Materials
Table 2
Thoracic aorta hemodynamics, diameter, and stiffness measurements.
Thoracic aorta
WKY
SHR basal
SHR
SHRLN basal
SHRLN
SHRLN
BP/WKY
BP/SHR
BP/WKY
Mean AP mmHg
138 ± 6
190 ± 5
127 ± 6
229 ± 7#
175 ± 11
138 ± 3
Systolic AP mmHg
160 ± 6
223 ± 7
151 ± 7
274 ± 9#
203 ± 12
161 ± 3
Diastolic AP mmHg
122 ± 6
163 ± 4
107 ± 5
198 ± 6#
154 ± 11
119 ± 2
Heart rate bpm
380 ± 20
362 ± 14
269 ± 10
378 ± 11
306 ± 27
264 ± 19
Pulse pressure mmHg
38 ± 1
61 ± 4
44 ± 3
77 ± 4#
50 ± 2#
42 ± 2
Local PWV m/s
5.7 ± 0.1
8.9 ± 0.5
5.5 ± 0.4
13.6 ± 0.7#
8.9 ± 0.8
6.4 ± 0.3
Mean diameter μm
2517 ± 68
2856 ± 49
2691 ± 75
3060 ± 51#
2897 ± 65
2853 ± 66
Diastolic diameter μm
2390 ± 68
2756 ± 49
2499 ± 87
2981 ± 48#
2808 ± 65
2732 ± 76
Aortic distension μm
176 ± 9
136 ± 8
231 ± 16
80 ± 5#
126 ± 19
179 ± 11#
Aortic distension %
7.4 ± 0.4
4.9 ± 0.3
9.3 ± 0.9
2.7 ± 0.1#
4.5 ± 0.7
6.6 ± 0.6#
Compliance 10−3mm2/kPa
140.3 ± 6.4
78.4 ± 8.1
174.7 ± 16.8
39.6 ± 4.9#
90.0 ± 15.6
145.8 ± 6.4
Distensibility 10−3/kPa
29.4 ± 1.1
12.7 ± 1.4
32.7 ± 4.3
5.4 ± 0.6#
14.3 ± 2.8
23.8 ± 2.1
Stiffness index
3.9 ± 0.2
6.7 ± 0.6
4.0 ± 0.4
12.8 ± 0.9#
7.3 ± 0.9#
4.9 ± 0.4
AUCp/ms: pulse pressure
16.3 ± 0.6
26.9 ± 1.5
20.3 ± 1.6
31.1 ± 1.4
20.6 ± 0.8#
18.2 ± 1.0
AUCd/ms 10−1: distension
3.7 ± 0.2
2.6 ± 0.2
5.0 ± 0.4
1.3 ± 0.1#
2.2 ± 0.4
3.3 ± 0.3#
distensibility index 10−2
22.9 ± 0.8
9.9 ± 1.0
25.3 ± 3.2
4.5 ± 0.5#
11.0 ± 2.1
18.4 ± 1.5
(AUCd/AUCp)
Compliance index
23.9 ± 1.3
13.7 ± 1.3
23.5 ± 2.4
7.1 ± 0.6#
13.6 ± 1.9
19.1 ± 1.6
n
5
6
6
8
5
7
Parameters measured and calculated via the echotracking at the thoracic aorta. Results are expressed as mean ± SEM. significantly different (P < 0.05) compared to WKY; #significantly different (P < 0.05) compared to SHR basal. The numbers of rats (n) are indicated at the bottom of the table.
