Chronic NO Restriction in Hypertensive Rats Increases Abdominal but Not Thoracic Aortic Intrinsic Stiffness via an Augmentation in Profibrotic Materials
Table 3
Abdominal aorta hemodynamics, diameter, and stiffness measurements.
Abdominal aorta
WKY
SHR basal
SHR
SHRLN basal
SHRLN
SHRLN
BP/WKY
BP/SHR
BP/WKY
Mean AP mmHg
139 ± 7
196 ± 4
134 ± 5
223 ± 8#
195 ± 4
133 ± 2
Systolic AP mmHg
164 ± 7
233 ± 6
160 ± 5
268 ± 11#
230 ± 6
157 ± 2
Diastolic AP mmHg
122 ± 7
166 ± 3
113 ± 5
192 ± 6#
169 ± 4
116 ± 2
Heart rate bpm
387 ± 15
368 ± 13
285 ± 7
368 ± 8
334 ± 20
270 ± 18
Pulse pressure mmHg
42 ± 1
66 ± 4
47 ± 2
77 ± 5
60 ± 3
41 ± 2#
Local PWV m/s
7.6 ± 0.4
10.6 ± 0.5
7.5 ± 0.4
16.4 ± 1.2#
15.1 ± 1.1#
10.0 ± 0.8#
Mean diameter μm
1529 ± 45
1695 ± 17
1616 ± 53
1799 ± 34
1744 ± 42
1738 ± 39
Diastolic diameter μm
1478 ± 45
1630 ± 22
1543 ± 58
1698 ± 34#
1665 ± 59
1675 ± 46
Aortic distension μm
72 ± 8
62 ± 4
88 ± 9
37 ± 5#
31 ± 4#
49 ± 8#
Aortic distension %
4.9 ± 0.6
3.8 ± 0.3
5.7 ± 0.6
2.2 ± 0.3#
1.8 ± 0.3#
3.0 ± 0.5#
Compliance 10−3mm2/kPa
30.7 ± 3.3
19.1 ± 1.7
36.3 ± 4.6
10.3 ± 1.3#
10.5 ± 1.4#
24.1 ± 3.0#
Distensibility 10−3/kPa
17.4 ± 1.6
8.7 ± 0.8
18.3 ± 2.2
4.3 ± 0.6#
4.6 ± 0.7#
10.8 ± 1.7#
Stiffness index
6.6 ± 0.7
9.3 ± 0.8
6.7 ± 0.5
20.4 ± 2.9#
19.2 ± 3.2#
12.5 ± 2.0#
AUCp/ms: pulse pressure
16.7 ± 0.6
29.0 ± 1.6
20.8 ± 1.1
30.5 ± 2.3
24.2 ± 1.8
16.0 ± 1.0#
AUCd/ms 10−1: distension
2.3 ± 0.3
1.9 ± 0.1
2.9 ± 0.3
1.1 ± 0.1#
0.9 ± 0.1#
1.4 ± 0.3#
distensibility index 10−2
13.4 ± 1.2
6.7 ± 0.6
14.4 ± 1.8
3.6 ± 0.5#
3.9 ± 0.6#
8.7 ± 1.3#
(AUCd/AUCp)
Compliance index
14.0 ± 1.0
9.8 ± 0.9
13.7 ± 1.2
5.7 ± 0.8#
5.3 ± 0.9#
8.5 ± 1.3#
n
5
6
6
8
5
7
Parameters measured and calculated via the echotracking at the thoracic aorta. Results are expressed as mean ± SEM. significantly different (P < 0.05) compared to WKY; #significantly different (P < 0.05) compared to SHR basal. The numbers of rats (n) are indicated at the bottom of the table.
