Effect of Nebivolol and Olmesartan on 24-Hour Brachial and Aortic Blood Pressure in the Acute Stage of Ischemic Stroke

Table 2

Comparisons of peripheral and central hemodynamic parameters between baseline and study-end by treatment group.

Parameter	Nebivolol 5 mg/day			Olmesartan 20 mg/day			No-treatment
	Baseline	Day 7	value	Baseline	Day 7	value	Baseline	Day 7	value
24-h brachial SBP (mmHg)	153.4 ± 19.1	141.1 ± 15.6	<0.001	151.7 ± 14.0	143.4 ± 16.9	0.032	154.3 ± 18.2	149.6 ± 19.2	0.08
24-h brachial DBP (mmHg)	83.1 ± 9.2	78.5 ± 8.8	0.001	84.7 ± 7.5	82.0 ± 8.5	0.011	85.4 ± 12.9	83.3 ± 12.0	0.13
24-h brachial PP (mmHg)	70.3 ± 14.5	62.6 ± 12.1	0.008	67.0 ± 10.2	61.4 ± 11.3	0.044	68.9 ± 11.9	66.3 ± 12.3	0.27
24-h heart rate (bpm)	73.8 ± 12.4	70.3 ± 13.7	0.030	71.9 ± 10.2	71.7 ± 10.9	>0.90	72.7 ± 14.3	74.2 ± 17.4	0.52
24-h MBP (mmHg)	114.1 ± 13.1	105.7 ± 9.8	<0.001	114.4 ± 9.7	109.0 ± 12.8	0.024	117.0 ± 14.4	114.7 ± 15.0	0.26
24-h aortic SBP (mmHg)	137.9 ± 18.7	126.1 ± 14.2	<0.001	140.9 ± 13.5	130.1 ± 15.5	0.006	140.3 ± 16.7	135.1 ± 19.9	0.10
24-h aortic DBP (mmHg)	85.6 ± 9.5	80.9 ± 9.7	0.001	86.9 ± 8.2	83.5 ± 9.5	0.042	87.1 ± 12.8	86.1 ± 13.9	0.55
24-h aortic PP (mmHg)	52.2 ± 13.9	45.2 ± 11.5	0.001	53.9 ± 9.3	46.5 ± 9.2	0.018	53.2 ± 9.9	49.0 ± 10.3	0.12
24-h aortic-to-brachial PP amplification (mmHg)	18.1 ± 7.7	17.4 ± 7.2	0.45	13.1 ± 7.1	14.9 ± 7.6	0.42	15.7 ± 4.9	17.3 ± 6.8	0.18
24-h AIx(75) (%)	34.0 ± 6.8	31.7 ± 8.7	0.047	34.7 ± 5.5	31.2 ± 7.4	0.038	34.1 ± 7.5	32.9 ± 10.0	0.40
24-h PWV (m/sec)	12.8 ± 1.8	12.0 ± 1.9	0.014	13.4 ± 2.3	12.6 ± 2.8	0.015	12.7 ± 2.0	12.2 ± 2.4	0.10

AIx(75) = heart rate-adjusted augmentation index; DBP = diastolic blood pressure; MBP = mean blood pressure; SBP = systolic blood pressure; PP = pulse pressure; PWV = pulse wave velocity; data are presented as mean ± SD.