Effect of Nebivolol and Olmesartan on 24-Hour Brachial and Aortic Blood Pressure in the Acute Stage of Ischemic Stroke

Table 3

Between-group differences in change from baseline to study-end of peripheral and central hemodynamic parameters.

Parameter	Nebivolol vs. olmesartan		Nebivolol vs. no-treatment		Olmesartan vs. no-treatment
	MD (95% CI)	value	MD (95% CI)	value	MD (95% CI)	value
24-h brachial SBP (mmHg)	−3.4 (−11.2, 4.3)	0.37	−7.8 (−15.6, −0.1)	0.049	−4.3 (−12.1, 3.4)	0.27
24-h brachial DBP (mmHg)	−2.2 (−6.0, 1.6)	0.25	−2.9 (−6.7, 0.9)	0.14	−0.7 (−4.5, 3.1)	0.73
24-h brachial PP (mmHg)	−0.6 (−6.9, 5.6)	0.83	−4.6 (−10.8, 1.6)	0.14	−3.9 (−10.1, 2.3)	0.21
24-h heart rate (bpm)	−2.8 (−9.7, 4.1)	0.42	−4.8 (−11.6, −0.1)	0.045	−1.9 (−8.8, 4.9)	0.57
24-h MBP (mmHg)	−3.2 (−9.5, 3.1)	0.31	−7.1 (−13.4, −0.8)	0.027	−3.9 (−10.2, 2.3)	0.21
24-h aortic SBP (mmHg)	−1.9 (−10.1, 6.2)	0.63	−7.3 (−12.5, −0.1)	0.048	−5.4 (−13.6, 2.7)	0.19
24-h aortic DBP (mmHg)	−1.6 (−6.4, 3.2)	0.50	−4.0 (−8.8, 0.8)	0.10	−2.4 (−7.2, 2.4)	0.32
24-h aortic PP (mmHg)	−0.6 (−6.5, 5.4)	0.85	−3.3 (−9.3, 2.6)	0.26	−2.8 (−8.8, 3.2)	0.35
24-h aortic-to-brachial PP amplification (mmHg)	−0.2 (−4.4, 3.9)	0.92	−1.3 (−5.3, 2.7)	0.52	−1.1 (−5.1, 2.9)	0.59
24-h AIx(75) (%)	1.2 (−2.8, 5.2)	0.54	−1.1 (−5.1, 2.8)	0.57	−2.4 (−6.3, 1.6)	0.24
24-h PWV (m/sec)	0.1 (−0.9, 0.9)	>0.90	−0.3 (−1.2, 0.7)	0.57	−0.3 (−1.2, 0.7)	0.57

AIx(75) = heart rate-adjusted augmentation index; CI = confidence interval; DBP = diastolic blood pressure; MBP = mean blood pressure; MD = mean difference; PP = pulse pressure; PWV = pulse wave velocity; SBP = systolic blood pressure; data are derived from univariate ANCOVA and are presented as mean between-group differences with corresponding 95% CI.