Clinical Study
Association of Lactate Dehydrogenase with In-Hospital Mortality in Patients with Acute Aortic Dissection: A Retrospective Observational Study
Table 1
Baseline characteristics of the patients (
).
| | Characteristic | Lactate dehydrogenase (μ/L) (tertile) | value | | Total | T1 (54.6–209.3) | T2 (209.7–274.7) | T3 (274.8–4981.0) |
| | No. of patients | 1526 | 504 | 511 | 511 | | | Age (years, mean ± sd) | 52.72 ± 11.94 | 53.71 ± 11.87 | 52.52 ± 11.82 | 51.94 ± 12.09 | 0.055 | | BMI (kg/m2, mean ± sd) | 25.03 ± 4.28 | 24.44 ± 3.94 | 25.20 ± 4.33 | 25.44 ± 4.49 | <0.001 | | Gender | | | | | 0.238 | | Male | 1227 (80.41%) | 397 (78.77%) | 407 (79.65%) | 423 (82.78%) | | | Female | 299 (19.59%) | 107 (21.23%) | 104 (20.35%) | 88 (17.22%) | | | Hypertension | | | | | 0.362 | | No | 469 (30.73%) | 162 (32.14%) | 162 (31.70%) | 145 (28.38%) | | | Yes | 1057 (69.27%) | 342 (67.86%) | 349 (68.30%) | 366 (71.62%) | | | Diabetes | | | | | 0.386 | | No | 1468 (96.20%) | 480 (95.24%) | 494 (96.67%) | 494 (96.67%) | | | Yes | 58 (3.80%) | 24 (4.76%) | 17 (3.33%) | 17 (3.33%) | | | Smoking | | | | | 0.501 | | No | 1044 (68.41%) | 337 (66.87%) | 359 (70.25%) | 348 (68.10%) | | | Yes | 482 (31.59%) | 167 (33.13%) | 152 (29.75%) | 163 (31.90%) | | | Stroke | | | | | 0.865 | | No | 1465 (96.00%) | 482 (95.63%) | 491 (96.09%) | 492 (96.28%) | | | Yes | 61 (4.00%) | 22 (4.37%) | 20 (3.91%) | 19 (3.72%) | | | Atherosclerosis | | | | | 0.002 | | No | 1393 (91.28%) | 443 (87.90%) | 470 (91.98%) | 480 (93.93%) | | | Yes | 133 (8.72%) | 61 (12.10%) | 41 (8.02%) | 31 (6.07%) | | | Symptom | | | | | 0.002 | | Chest pain | 1166 (76.41%) | 362 (71.83%) | 401 (78.47%) | 403 (78.86%) | | | Back pain | 69 (4.52%) | 27 (5.36%) | 26 (5.09%) | 16 (3.13%) | | | Abdominal pain | 108 (7.08%) | 37 (7.34%) | 29 (5.68%) | 42 (8.22%) | | | Syncope | 19 (1.25%) | 5 (0.99%) | 3 (0.59%) | 11 (2.15%) | | | Other | 164 (10.75%) | 73 (14.48%) | 52 (10.18%) | 39 (7.63%) | | | Type of AAD (Stanford) | | | | | <0.001 | | A | 703 (46.07%) | 200 (39.68%) | 221 (43.25%) | 282 (55.19%) | | | B | 823 (53.93%) | 304 (60.32%) | 290 (56.75%) | 229 (44.81%) | | | SBP (mmHg, mean ± sd) | 145.97 ± 29.23 | 144.38 ± 27.12 | 147.46 ± 28.13 | 146.05 ± 32.15 | 0.242 | | DBP (mmHg, mean ± sd) | 81.79 ± 18.14 | 81.10 ± 16.21 | 82.98 ± 17.82 | 81.28 ± 20.14 | 0.189 | | WBC (×109/L, mean ± sd) | 11.21 ± 4.15 | 9.79 ± 3.50 | 11.28 ± 3.81 | 12.55 ± 4.59 | <0.001 | | Hb (g/L, mean ± sd) | 124.96 ± 20.83 | 123.54 ± 20.72 | 125.94 ± 20.38 | 125.40 ± 21.34 | 0.158 | | ALT (μ/L, mean ± sd) | 78.85 ± 422.73 | 22.44 ± 17.32 | 33.49 ± 41.04 | 179.85 ± 718.99 | <0.001 | | AST (μ/L, mean ± sd) | 100.92 ± 639.72 | 22.16 ± 16.13 | 28.49 ± 27.54 | 251.03 ± 1090.29 | <0.001 | | ALB (g/L, mean ± sd) | 35.61 ± 4.62 | 35.49 ± 4.48 | 35.81 ± 4.65 | 35.53 ± 4.72 | 0.483 | | Cr (μmol/L, mean ± sd) | 116.16 ± 135.88 | 109.73 ± 146.47 | 101.39 ± 95.58 | 137.28 ± 155.59 | <0.001 | | Management | | | | | <0.001 | | Medical | 412 (27.00%) | 130 (25.79%) | 118 (23.09%) | 164 (32.09%) | | | Endovascular | 647 (42.40%) | 236 (46.83%) | 230 (45.01%) | 181 (35.42%) | | | Surgical | 467 (30.60%) | 138 (27.38%) | 163 (31.90%) | 166 (32.49%) | | | Mortality | | | | | <0.001 | | Survivor | 1229 (80.54%) | 423 (83.93%) | 429 (83.95%) | 377 (73.78%) | | | Nonsurvivor | 297 (19.46%) | 81 (16.07%) | 82 (16.05%) | 134 (26.22%) | | | Length of stay in hospital (d) | 16.06 ± 10.11 | 16.55 ± 9.72 | 16.36 ± 9.34 | 15.27 ± 11.15 | 0.097 | | Length of stay in ICU (d) | 2.18 ± 5.08 | 1.78 ± 4.55 | 2.14 ± 5.20 | 2.56 ± 5.38 | 0.221 |
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Abbreviations: BMI, body mass index; SBP, systolic blood pressure; DBP, diastole blood pressure; WBC, white blood cell; Hb, hemoglobin; ALT, alanine transaminase; AST, aspartate aminotransferase; ALB, albumin; Cr, creatinine; AAD, acute aortic dissection.
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