Polymorphism of MTHFR C677T Gene and the Associations with the Severity of Essential Hypertension in Northern Chinese Population

Table 2

Genotypes and allele frequency of methylenetetrahydrofolate reductase C677T in theG cohort recruited.

Group	N	Genotype frequency (%)			Allele frequency (%)		value
		CC	CT	TT	C	T
Total	985	193	492	300	878	1092
		(19.59)	(49.95)	(30.46)	(44.57)	(55.43)
Gender							0.053
Males	617	130	290	197	550	684
		(21.07)	(47.00)	(31.93)	(44.57)	(55.43)
Females	368	63	202	103	328	408
		(17.12)	(54.89)	(27.99)	(44.57)	(55.43)
Age							0.363
<45	143	25	76	42	126	160
		(17.48)	(53.15)	(29.37)	(44.06)	(55.94)
45–59	390	77	205	108	359	421
		(19.74)	(52.56)	(27.69)	(46.03)	(53.97)
≥60	452	91	211	150	393	511
		(20.13)	(46.68)	(33.19)	(43.47)	(56.53)

CC is the “normal” genotype, CT the heterozygote, and TT the homozygote abnormal.