High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease

Table 1

Clinical variables of the 90 coronary artery disease patients according to the serum median of angiopoietin-like protein 3 levels.

Variables	All participants (n = 90)	Low ANGPL3 group (n = 45)	High ANGPL3 group (n = 45)	value
Age (years)	65.51 ± 9.02	67.04 ± 10.04	63.98 ± 7.69	0.107
Height (cm)	161.14 ± 8.18	161.80 ± 7.61	160.49 ± 8.75	0.456
Body weight (kg)	68.61 ± 12.26	69.07 ± 12.46	68.15 ± 12.18	0.724
Body mass index (kg/m^2)	26.31 ± 3.52	26.29 ± 3.76	26.33 ± 3.30	0.960
Systolic blood pressure (mmHg)	131.08 ± 16.66	129.78 ± 16.65	132.38 ± 16.76	0.462
Diastolic blood pressure (mmHg)	71.99 ± 9.46	73.27 ± 9.62	70.71 ± 9.23	0.202
Total cholesterol (mg/dL)	163.60 ± 32.20	160.09 ± 28.86	167.11 ± 35.21	0.304
Triglycerides (mg/dL)	127.50 (88.75–181.00)	127.00 (91.00–155.50)	128.00 (88.50–201.00)	0.634
HDL-C (mg/dL)	43.81 ± 11.43	43.36 ± 9.25	43.27 ± 13.35	0.758
LDL-C (mg/dL)	95.76 ± 26.61	92.64 ± 25.56	98.87 ± 27.55	0.270
Fasting glucose (mg/dL)	111.00 (95.75–150.50)	111.00 (94.00–167.50)	111.00 (98.50–134.00)	0.865
Blood urea nitrogen (mg/dL)	16.00 (13.00–19.00)	16.00 (14.00–19.00)	16.00 (13.00–19.00)	0.509
Creatinine (mg/dL)	1.10 (0.90–1.30)	1.10 (0.90–1.25)	1.10 (0.90–1.30)	0.687
eGRF (mL/min)	68.53 ± 18.17	68.71 ± 19.77	69.02 ± 18.59	0.936
ANGPTL3 (ng/mL)	222.37 (152.57–320.12)	152.94 (93.10–197.90)	318.40 (278.94–463.04)	<0.001
C-reactive protein (mg/dL)	0.20 (0.14–0.26)	0.17 (0.13–0.20)	0.26 (0.18–0.39)	<0.001
Female (%)	23 (25.6)	9 (20.0)	14 (31.1)	0.227
Diabetes (%)	44 (48.9)	22 (48.9)	22 (48.9)	1.000
Hypertension (%)	70 (77.8)	37 (82.2)	33 (73.2)	0.310
ACE inhibitor use	28 (31.1)	15 (33.3)	13 (28.9)	0.649
ARB use	36 (40.0)	18 (40.0)	18 (40.0)	1.000
β-blocker use	54 (60.0)	29 (64.4)	25 (55.6)	0.389
CCB use	30 (33.3)	17 (37.8)	13 (28.9)	0.371
Statin use	67 (74.4)	33 (73.3)	34 (75.6)	0.809
Fibrate use	16 (17.8)	10 (22.2)	6 (13.3)	0.270
One-vessel CAD	37 (41.1)	23 (51.1)	14 (31.1)	0.151
Two-vessel CAD	30 (33.3)	12 (26.7)	18 (40.0)
Three-vessel CAD	23 (25.6)	10 (22.2)	13 (28.9)

Values for continuous variables are given as means ± standard deviation and compared by Student's t-test; variables not normally distributed are given as medians and interquartile range and compared by Mann–Whitney U test; values are presented as number (%), and analysis was performed using the chi-square test. HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; eGFR, estimated glomerular filtration rate; ANGPTL3, angiopoietin-like protein 3; ACE, angiotensin-converting enzyme; ARB, angiotensin-receptor blocker; CCB, calcium-channel blocker; and CAD, coronary artery disease. was considered statistically significant.