High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease

Table 2

Clinical variables of the 90 coronary artery disease patients with or without the cardiovascular event.

Variables	Participants without cardiovascular events (n = 57)	Participants with cardiovascular events (n = 33)	value
Age (years)	65.70 ± 9.29	65.18 ± 8.68	0.794
Height (cm)	161.11 ± 8.70	161.21 ± 7.31	0.953
Body weight (kg)	68.74 ± 12.32	68.38 ± 12.34	0.896
Body mass index (kg/m^2)	26.39 ± 3.61	26.18 ± 3.41	0.793
Systolic blood pressure (mmHg)	128.82 ± 15.85	134.97 ± 17.55	0.092
Diastolic blood pressure (mmHg)	71.16 ± 9.54	73.42 ± 9.30	0.276
Total cholesterol (mg/dL)	159.65 ± 30.44	170.42 ± 34.45	0.127
Triglycerides (mg/dL)	111.00 (87.50–153.00)	150.00 (90.50–208.00)	0.117
HDL-C (mg/dL)	42.72 ± 9.81	45.70 ± 13.75	0.236
LDL-C (mg/dL)	93.93 ± 26.58	98.91 ± 26.77	0.395
Fasting glucose (mg/dL)	107.00 (96.50–132.50)	111.00 (95.00–181.50)	0.533
Blood urea nitrogen (mg/dL)	16.00 (14.00–19.00)	15.00 (12.00–19.00)	0.176
Creatinine (mg/dL)	1.10 (0.90–1.30)	1.00 (0.90–1.25)	0.187
eGFR (mL/min)	66.36 ± 17.04	72.27 ± 19.69	0.138
ANGPTL3 (ng/mL)	206.67 (110.39–274.38)	318.40 (195.56–490.61)	<0.001
C-reactive protein (mg/dL)	0.16 (0.12–0.21)	0.26 (0.21–0.55)	<0.001
Female (%)	15 (26.3)	8 (24.2)	0.828
Diabetes (%)	25 (43.9)	19 (57.6)	0.210
Hypertension (%)	43 (75.4)	23 (81.8)	0.483
ACE inhibitor use	21 (36.8)	7 (21.2)	0.123
ARB use	21 (36.8)	15 (45.5)	0.422
β-blocker use	33 (57.9)	21 (63.6)	0.592
CCB use	17 (29.8)	13 (39.4)	0.353
Statin use	47 (82.5)	20 (60.6)	0.022
Fibrate use	8 (14.0)	8 (24.2)	0.222
One-vessel CAD	33 (57.9)	4 (12.1)	<0.001
Two-vessel CAD	14 (24.6)	16 (48.5)
Three-vessel CAD	10 (17.5)	13 (39.4)

Values for continuous variables are given as means ± standard deviation and compared by Student's t-test; variables not normally distributed are given as medians and interquartile range and compared by Mann–Whitney U test; values are presented as number (%), and analysis was performed using the chi-square test. HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; eGFR, estimated glomerular filtration rate; ANGPTL3, angiopoietin-like protein 3; ACE, angiotensin-converting enzyme; ARB, angiotensin-receptor blocker; CCB, calcium-channel blocker; and CAD, coronary artery disease. was considered statistically significant.