Research Article
p38/JNK Is Required for the Proliferation and Phenotype Changes of Vascular Smooth Muscle Cells Induced by L3MBTL4 in Essential Hypertension
Figure 1
p38/JNK was required for elevated blood pressure and left ventricular hypertrophy mediated by L3MBTL4. (a) The systolic blood pressure (SBP) in TGs, compared with TG + SP600125 and TG + SB2003580. (b)–(f) SBP, diastolic blood pressure (DBP), mean blood pressure (MBP), heart rate (HR), and bodyweight (BW) of WTs, TG + normal saline, TG + SP600125, and TG + SB2003580 (n = 5 each group). (g)–(i) Quantitative analysis of left ventricle + septum weight/bodyweight (LV + SW/BW), right ventricle weight/bodyweight (RVW/BW), and heart weight/bodyweight (HW/BW) ratios in each group (n = 5 each group). ; ; . All data represent mean ± SEM.
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