Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study

Table 2

Association of the polygenic risk score with salt sensitivity.

	Model A		Model B		Model C
	OR (95% CI)		OR (95% CI)		OR (95% CI)
All
PRS	1.081 (1.035, 1.129)	<0.001	1.082 (1.036, 1.130)	<0.001	1.083 (1.037, 1.132)	<0.001
PRS tertiles
1st vs 2nd	1.694 (1.083, 2.652)	0.021	1.702 (1.085, 2.668)	0.020	1.725 (1.095, 2.716)	0.019
1st vs 3rd	1.897 (1.205, 2.985)	0.006	1.913 (1.214, 3.015)	0.005	1.960 (1.233, 3.113)	0.004
Hypertension
PRS	1.052 (0.987, 1.121)	0.117	1.054 (0.989, 1.124)	0.104	1.058 (0.991, 1.129)	0.091
PRS tertiles
1st vs 2nd	1.377 (0.714, 2.658)	0.340	1.370 (0.708, 2.651)	0.350	1.369 (0.703, 2.666)	0.356
1st vs 3rd	1.582 (0.818, 3.057)	0.173	1.614 (0.832, 3.128)	0.157	1.654 (0.840, 3.260)	0.146
Normotensives
PRS	1.106 (1.042, 1.174)	0.001	1.112 (1.048, 1.181)	0.001	1.109 (1.044, 1.179)	0.001
PRS tertiles
1st vs 2nd	2.096 (1.123, 3.912)	0.020	2.186 (1.162, 4.114)	0.015	2.179 (1.154, 4.116)	0.016
1st vs 3rd	2.300 (1.219, 4.340)	0.010	2.378 (1.251, 4.522)	0.008	2.281 (1.189, 4.376)	0.013

PRS, polygenic risk score. Model A: no variables were adjusted; model B: age and sex adjusted; model C: age, sex, smoking, BMI, dyslipidemia, and DM adjusted. ; .