Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study
Table 3
Association of the polygenic risk score with salt sensitivity during the process of acute salt loading and diuresis shrinkage.
Model A
Model B
Model C
OR (95% CI)
OR (95% CI)
OR (95% CI)
All
Acute salt loading§
PRS
1.087 (1.040, 1.137)
<0.001
1.089 (1.041, 1.138)
<0.001∗∗
1.091 (1.043, 1.141)
<0.001
PRS tertiles
1st vs 2nd
1.728 (1.090, 2.738)
0.020
1.721 (1.085, 2.732)
0.021
1.754 (1.100, 2.797)
0.018
1st vs 3rd
1.924 (1.207, 3.065)
0.006
1.939 (1.215, 3.092)
0.005
2.011 (1.251, 3.234)
0.004
Diuresis shrinkage¤
PRS
1.058 (0.975, 1.148)
0.175
1.057 (0.974, 1.147)
0.181
1.054 (0.970, 1.144)
0.216
PRS tertiles
1st vs 2nd
1.481 (0.610, 3.596)
0.386
1.500 (0.617, 3.648)
0.371
1.459 (0.597, 3.568)
0.407
1st vs 3rd
1.781 (0.743, 4.271)
0.196
1.777 (0.740, 4.262)
0.198
1.676 (0.690, 4.069)
0.254
Hypertension
Acute salt loading
PRS
1.058 (0.991, 1.130)
0.089
1.062 (0.994, 1.134)
0.076
1.062 (0.994, 1.135)
0.076
PRS tertiles
1st vs 2nd
1.630 (0.832, 3.190)
0.154
1.620 (0.824, 3.187)
0.162
1.608 (0.813, 3.183)
0.172
1st vs 3rd
1.558 (0.786, 3.087)
0.204
1.603 (0.805, 3.193)
0.179
1.623 (0.803, 3.283)
0.178
Diuresis shrinkage
PRS
0.980 (0.867, 1.107)
0.740
0.981 (0.868, 1.108)
0.756
0.982 (0.865, 1.113)
0.771
PRS tertile
1st vs 2nd
0.829 (0.226, 3.046)
0.777
0.823 (0.224, 3.029)
0.769
0.819 (0.219, 3.062)
0.766
1st vs 3rd
1.111 (0.326, 3.791)
0.866
1.116 (0.326, 3.818)
0.861
1.190 (0.335, 4.232)
0.788
Normotensives
Acute salt loading
PRS
1.113 (1.047, 1.184)
0.001
1.117 (1.051, 1.188)
<0.001
1.115 (1.048, 1.187)
0.001
PRS tertiles
1st vs 2nd
1.887 (0.995, 3.580)
0.052
1.934 (1.014, 3.685)
0.045
1.939 (1.012, 3.712)
0.046
1st vs 3rd
2.341 (1.229, 4.460)
0.010
2.390 (1.249, 4.572)
0.009
2.298 (1.189, 4.442)
0.013
Diuresis shrinkage
PRS
1.129 (1.007, 1.266)
0.038
1.133 (1.009, 1.272)
0.035
1.135 (1.010, 1.275)
0.034
PRS tertiles
1st vs 2nd
2.717 (0.702, 10.515)
0.148
2.878 (0.739, 11.211)
0.128
2.988 (0.749, 11.915)
0.121
1st vs 3rd
3.092 (0.797, 11.991)
0.103
3.178 (0.816, 12.380)
0.096
3.025 (0.803, 12.786)
0.099
PRS, polygenic risk score. Model A: no variables were adjusted; model B: age and sex adjusted; model C: age, sex, smoking, BMI, dyslipidemia, and DM adjusted.§Logistic regression was used; assignment of dependent variables: MAP raises more than 5 mmHg in the process of acute salt loading assigned to 1, and MAP raises less than 5 mmHg in the process of acute salt loading assigned to 0. Logistic regression was used; assignment of dependent variables: MAP reduces more than 10 mmHg in the process of diuresis shrinkage assigned to 1, and MAP reduces less than 10 mmHg in the process of diuresis shrinkage assigned to 0. ;.
