International Journal of Hypertension / 2020 / Article / Tab 3

Research Article

Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study

Table 3

Association of the polygenic risk score with salt sensitivity during the process of acute salt loading and diuresis shrinkage.

Model AModel BModel C
OR (95% CI)OR (95% CI)OR (95% CI)

All
 Acute salt loading§
  PRS1.087 (1.040, 1.137)<0.0011.089 (1.041, 1.138)<0.001∗∗1.091 (1.043, 1.141)<0.001
  PRS tertiles
   1st vs 2nd1.728 (1.090, 2.738)0.0201.721 (1.085, 2.732)0.0211.754 (1.100, 2.797)0.018
   1st vs 3rd1.924 (1.207, 3.065)0.0061.939 (1.215, 3.092)0.0052.011 (1.251, 3.234)0.004
 Diuresis shrinkage¤
  PRS1.058 (0.975, 1.148)0.1751.057 (0.974, 1.147)0.1811.054 (0.970, 1.144)0.216
  PRS tertiles
   1st vs 2nd1.481 (0.610, 3.596)0.3861.500 (0.617, 3.648)0.3711.459 (0.597, 3.568)0.407
   1st vs 3rd1.781 (0.743, 4.271)0.1961.777 (0.740, 4.262)0.1981.676 (0.690, 4.069)0.254
Hypertension
 Acute salt loading
  PRS1.058 (0.991, 1.130)0.0891.062 (0.994, 1.134)0.0761.062 (0.994, 1.135)0.076
  PRS tertiles
   1st vs 2nd1.630 (0.832, 3.190)0.1541.620 (0.824, 3.187)0.1621.608 (0.813, 3.183)0.172
   1st vs 3rd1.558 (0.786, 3.087)0.2041.603 (0.805, 3.193)0.1791.623 (0.803, 3.283)0.178
 Diuresis shrinkage
  PRS0.980 (0.867, 1.107)0.7400.981 (0.868, 1.108)0.7560.982 (0.865, 1.113)0.771
  PRS tertile
   1st vs 2nd0.829 (0.226, 3.046)0.7770.823 (0.224, 3.029)0.7690.819 (0.219, 3.062)0.766
   1st vs 3rd1.111 (0.326, 3.791)0.8661.116 (0.326, 3.818)0.8611.190 (0.335, 4.232)0.788
Normotensives
 Acute salt loading
  PRS1.113 (1.047, 1.184)0.0011.117 (1.051, 1.188)<0.0011.115 (1.048, 1.187)0.001
  PRS tertiles
   1st vs 2nd1.887 (0.995, 3.580)0.0521.934 (1.014, 3.685)0.0451.939 (1.012, 3.712)0.046
   1st vs 3rd2.341 (1.229, 4.460)0.0102.390 (1.249, 4.572)0.0092.298 (1.189, 4.442)0.013
 Diuresis shrinkage
  PRS1.129 (1.007, 1.266)0.0381.133 (1.009, 1.272)0.0351.135 (1.010, 1.275)0.034
  PRS tertiles
   1st vs 2nd2.717 (0.702, 10.515)0.1482.878 (0.739, 11.211)0.1282.988 (0.749, 11.915)0.121
   1st vs 3rd3.092 (0.797, 11.991)0.1033.178 (0.816, 12.380)0.0963.025 (0.803, 12.786)0.099

PRS, polygenic risk score. Model A: no variables were adjusted; model B: age and sex adjusted; model C: age, sex, smoking, BMI, dyslipidemia, and DM adjusted.§Logistic regression was used; assignment of dependent variables: MAP raises more than 5 mmHg in the process of acute salt loading assigned to 1, and MAP raises less than 5 mmHg in the process of acute salt loading assigned to 0. Logistic regression was used; assignment of dependent variables: MAP reduces more than 10 mmHg in the process of diuresis shrinkage assigned to 1, and MAP reduces less than 10 mmHg in the process of diuresis shrinkage assigned to 0. ;.

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