Association between Plasma Urotensin II and Risk of Hypertension: Findings from a Prospective Study

Table 3

Odds ratios for risk of hypertension comparing the three higher quartiles with the lowest quartile of baseline urotensin II levels.

	Quartile of plasma urotensin II				value for trend
	Quartile 1 (n = 453)	Quartile 2 (n = 456)	Quartile 3 (n = 455)	Quartile 4 (n = 455)
Number of new cases of HTN (%)	188 (41.5)	190 (41.7)	173 (38.0)	172 (37.8)
Model 1^a	1.000	1.008 (0.772–1.317)	0.848 (0.647–1.110)	0.870 (0.665–1.140)	0.573
Model 2^b	1.000	1.119 (0.829–1.511)	1.046 (0.774–1.414)	0.930 (0.688–1.256)	0.910
Model 3^c	1.000	1.096 (0.811–1.481)	1.037 (0.766–1.403)	0.923 (0.683–1.248)	0.948
Model 4^d	1.000	0.993 (0.753–1.310)	0.860 (0.650–1.140)	0.879 (0.664–1.163)	0.775

^aAdjusted for age and sex; ^badjusted for age, sex, and systolic blood pressure at baseline; ^cadjusted for age, sex, systolic blood pressure, drinking, smoking, and family history of hypertension; ^dadjusted for age, sex, systolic blood pressure, drinking, smoking, family history of hypertension, body mass index, fasting plasma glucose, total cholesterol, and endothelin-1; HTN, hypertension.