Elevated Lipoprotein-Associated Phospholipase A2 Independently Affects Age-Related Increases in Systolic Blood Pressure: A Nested Case-Control Study in a Prospective Korean Cohort
Table 1
Clinical characteristics of hypertension controls and cases at baseline and follow-up.
Controls (n = 242)
Hypertension (n = 121)
Baseline
Follow-up
Baseline
Follow-up
BMI (kg/m2)
23.7 ± 0.18
23.8 ± 0.18
24.9 ± 0.26
25.2 ± 0.25
—
—
Change
0.06 ± 0.05
0.33 ± 0.08
0.001
Systolic BP (mmHg)
116.8 ± 0.71
116.3 ± 0.70
126.0 ± 0.86
140.8 ± 0.82
<0.001
<0.001
Change
−0.52 ± 0.73
14.8 ± 1.05
<0.001
Diastolic BP (mmHg)
73.8 ± 0.54
72.9 ± 0.55
79.9 ± 0.66
90.8 ± 0.65
<0.001
<0.001
Change
−0.87 ± 0.54
10.9 ± 0.63
<0.001
Triglyceride (mg/dL)∮
123.9 ± 4.90
122.1 ± 4.96
131.5 ± 6.43
148.6 ± 10.4
0.754
0.120
Change
−1.83 ± 3.90
17.2 ± 7.61
0.007
Total cholesterol (mg/dL)∮
197.4 ± 2.11
199.2 ± 2.12
197.2 ± 3.04
206.0 ± 3.28
0.470
0.117
Change
1.81 ± 1.62
8.83 ± 2.40
0.010
HDL-cholesterol (mg/dL)∮
52.5 ± 0.85
51.9 ± 0.90
51.6 ± 1.14
51.1 ± 1.07
0.609
0.307
Change
−0.60 ± 0.65
−0.55 ± 0.86
0.856
LDL-cholesterol (mg/dL)∮
120.8 ± 2.00
123.5 ± 1.82
120.5 ± 2.78
127.3 ± 2.89
0.428
0.570
Change
2.72 ± 1.53
6.78 ± 2.10
0.094
Glucose (mg/dL)∮
91.4 ± 0.66
91.8 ± 0.65
92.6 ± 1.12
95.2 ± 1.25
0.757
0.057
Change
0.42 ± 0.59
2.66 ± 0.94
0.008
Insulin (μIU/dL)∮
9.05 ± 0.40
8.87 ± 0.44
8.48 ± 0.31
9.42 ± 0.43
0.096
0.925
Change
−0.17 ± 0.54
0.94 ± 0.39
0.302
HOMA-IR∮
2.06 ± 0.11
2.03 ± 0.10
1.92 ± 0.07
2.21 ± 0.11
0.100
0.672
Change
−0.03 ± 0.14
0.29 ± 0.11
0.208
hs-CRP (mg/dL)∮
1.00 ± 0.11
1.24 ± 0.22
1.48 ± 0.23
1.32 ± 0.21
0.013
0.985
Change
0.23 ± 0.24
−0.15 ± 0.30
0.889
TNF-α (pg/mL)∮
9.83 ± 0.74
10.2 ± 1.22
11.5 ± 1.37
10.7 ± 0.92
0.487
0.067
Change
0.39 ± 0.92
−0.78 ± 1.57
0.726
IL-1β (pg/mL)∮
0.73 ± 0.06
0.74 ± 0.07
0.91 ± 0.10
0.86 ± 0.06
0.028
0.003
Change
0.01 ± 0.04
−0.05 ± 0.10
0.969
IL-6 (pg/mL)∮
3.64 ± 0.25
3.61 ± 0.23
4.10 ± 0.34
3.92 ± 0.36
0.086
0.420
Change
−0.03 ± 0.22
−0.18 ± 0.43
0.806
Mean ± SE. ∮tested by logarithmic transformation. -values derived from an independent t-test and adjusted for BMI at baseline. -values derived from an independent t-test and adjusted for BMI at follow-up. -values derived from an independent t-test and adjusted for baseline values at the changed value. are derived from a paired t-test.
