High Neutrophil-to-Lymphocyte Ratio Predicts Hemorrhagic Transformation in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis

Table 2

Comparisons of clinicial and laboratory variables in IVT patients with and without HT.

Variable	With HT; (N = 72)	Without HT; (N = 213)	t/X^2/z; value	value
Age^a (years)	64.0 ± 12.3	61.8 ± 11.9	−1.354	0.177
Men^b	51 (70.8%)	150 (70.4%)	0.004	0.947
NIHSS score on admission^c	10 (6–14.8)	6 (4–9)	−5.429	<0.001
Hypertension^b	46 (63.9%)	165 (77.5%)	5.159	0.023
Diabetes^b	19 (26.4%)	60 (28.2%)	0.085	0.770
Smokers^b	25 (34.7%)	77 (36.2%)	0.048	0.827
AF^b	35 (48.6%)	32 (15.0%)	33.759	<0.001
Previous stroke^b	13 (18.1%)	39 (18.3%)	0.002	0.961
PAT^b	3 (4.2%)	20 (9.4%)	1.979	0.213
POAT^b	3 (4.2%)	5 (2.3%)	0.653	0.421
Antiplatelet therapy prescribed before MRI scan^b	45 (62.5%)	167 (78.4%)	2.315	0.128
Uric acid^a (mmol/L)	369.2 ± 108.8	396.9 ± 107.9	1.844	0.066
OTT^a (minutes)	195.3 ± 52.6	202.2 ± 56.9	0.898	0.37
Platelet counts^a (10^9/L)	201.3 ± 43.2	218.3 ± 59.0	2.246	0.025
WBC counts^a (10^9/L)	8.6 ± 3.2	8.4 ± 2.8	−0.586	0.558
Neutrophil counts (10^9/L)	6.3 ± 3.3	5.6 ± 2.6	−1.759	0.08
Lymphocyte counts (10^9/L)	1.6 ± 0.7	2.1 ± 0.9	4.349	<0.001
High NLR^c	27 (37.5%)	44 (20.7%)	8.16	0.004
BG on admission^a (mmol/L)	7.6 ± 3.4	7.5 ± 3.2	−0.280	0.779
SBP on admission^a (mmHg)	152.0 ± 24.1	159.2 ± 24.8	2.135	0.035
DBP on admission^a (mmHg)	90.1 ± 15.0	91.8 ± 17.0	0.754	0.452
SVD burden^c	0 (0–1)	1 (0–2)	−1.434	0.152

^aMean (SD), t-test; ^bn (%), chi-square test; ^cMann-Whitney U test. AF = atrial fibrillation; BG = blood glucose; DBP = diastolic blood pressure; HT = hemorrhagic transformation; NIHSS = National Institutes of Health Stroke Scale; NLR = neutrophil-to-lymphocyte ratio; OTT = onset-to-treatment time; PAT = previous antiplatelet therapy; POAT = previous oral anticoagulant therapy; SBP = systolic blood pressure; SVD = small vessel disease; WBC = white blood cell.