Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients

Table 1

Clinical characteristics of study participants according to platelet count.

Characteristics	Low platelet count (<210 × 10^9/L)	High platelet count (≥210 × 10^9/L)
No. of participants	21,980	8,389
Age (years)	63.3 ± 7.1	61.7 ± 7.2	<0.001
Sex, men (%)	11,087 (50.44)	3,516 (41.91)	<0.001
Antihypertensive medication, n (%)	18,897 (85.97)	7,312 (87.16)	0.007
Body mass index (kg/m^2)	24.71 ± 3.36	25.08 ± 3.31	<0.001
Fasting glucose (mmol/L)	5.92 ± 1.48	5.94 ± 1.46	0.252
Total cholesterol (mmol/L)	4.82 ± 1.01	5.10 ± 1.04	<0.001
Triglycerides (mmol/L)	1.80 ± 1.40	1.96 ± 1.43	<0.001
LDL-C (mmol/L)	2.78 ± 0.81	3.06 ± 0.84	<0.001
HDL-C (mmol/L)	1.49 ± 0.48	1.47 ± 0.45	<0.001
Creatinine (mmol/L)	73.37 ± 36.96	69.57 ± 30.47	<0.001
Systolic blood pressure (mmHg)	143.8 ± 17.6	144.6 ± 17.5	<0.001
Diastolic blood pressure (mmHg)	83.0 ± 10.5	84.0 ± 10.7	<0.001
Log-Hcy	2.40 ± 0.49	2.41 ± 0.48	0.037
Platelet consumption
Mean platelet volume (fL)	10.10 ± 1.75	8.87 ± 1.45	<0.001
Platelet crit (%)	0.1559 ± 0.0350	0.2192 ± 0.0450	<0.001
Platelet distribution width (%)	16.36 ± 0.93	15.90 ± 1.08	<0.001

All results are expressed in mean ± SD unless otherwise noted. LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; Log-Hcy: log-transformed homocysteine.