Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients

Table 3

Moderation of platelet count on the association between serum homocysteine and blood pressure.

Independent variables	Model 1			Model 2
	β (SE)		R^2	β (SE)		R^2
z-transformed SBP
z-transformed log-Hcy	0.007 (0.006)	0.240	0.0478	0.007 (0.006)	0.271	0.0479
z-transformed platelet count	0.017 (0.006)	0.004		0.017 (0.006)	0.005
Interaction term	—	—		−0.011 (0.006)	0.057
Moderation tests	ΔR^2 = 0.0001, F = 2.9585,
z-transformed DBP
z-transformed log-Hcy	0.036 (0.006)	<0.001	0.0975	0.035 (0.006)	<0.001	0.0980
z-transformed platelet count	0.019 (0.006)	0.001		0.019 (0.006)	0.001
Interaction term	—	—		−0.021 (0.005)	<0.001
Moderation tests	ΔR^2 = 0.0005, F = 14.734,

Log-Hcy: log-transformed homocysteine; model 1: the regression of blood pressure on z‐transformed log-Hcy and z‐transformed platelet count, adjusting for age, sex, body mass index, fasting glucose, lipids, and creatinine; model 2: further adjusting for the interaction term of z‐transformed log‐Hcy and z‐transformed platelet count.