Effects of L-/N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients

Figure 1

Study design. Patients received either 10 mg per day of cilnidipine, which was increased to a daily dose of 20 mg, or 5 mg per day of amlodipine, which was increased to a daily dose of 10 mg. Doses of RAS inhibitors were not altered when the combination with amlodipine failed to reduce BP to the target level within 3 months. Instead, additional antihypertensive medications, such as diuretics, were administered to achieve the target BP.