Association between Single Nucleotide Polymorphisms in Cardiovascular Developmental Critical Genes and Hypertension: A Propensity Score Matching Analysis

Table 4

The association between SNPs and hypertension.

Variables	Unadjusted^1		Adjusted^2
	OR (95% CI)	value	OR (95% CI)	value
Additive model
rs833061
TT	Reference		Reference
CT	1.114 (0.739, 1.680)	0.606	0.983 (0.423, 2.287)	0.969
CC	0.400 (0.184, 0.870)	0.021	0.219 (0.036, 1.342)	0.101
rs3025010
TT	Reference		Reference
CT	0.850 (0.563, 1.284)	0.441	0.476 (0.210, 1.079)	0.075
CC	0.392 (0.179, 0.858)	0.019	0.103 (0.019, 0.551)	0.008
Dominant model
rs833061
TT	Reference		Reference
CT + CC	0.898 (0.620, 1.302)	0.571	1.458 (0.749, 2.840)	0.267
rs3025010
TT	Reference		Reference
CT + CC	0.730 (0.499, 1.068)	0.105	0.354 (0.147, 0.854)	0.021
Recessive model
rs833061
TT + CT	Reference		Reference
CC	0.391 (0.181, 0.846)	0.017	0.114 (0.012, 1.073)	0.058
rs3025010
TT + CT	Reference		Reference
CC	0.409 (0.188, 0.888)	0.024	0.240 (0.042, 1.380)	0.110

¹OR and values: unadjusted values in univariate analysis. ²OR and values: multivariate analysis. We adjusted age, gender, BMI, smoking, drinking, and physical activity for both rs833061 and rs3025010 in all three models. Besides, in the additive model, rs833069, rs3025010, rs2146323, rs3212278, rs2305948, rs7667298, rs7671745, and rs3025053 were adjusted for rs833061, and rs2305948, rs3212278, rs7671745, rs833069, and rs2146323 were adjusted for rs3025010; in the dominant model, rs3025010 and rs3212278 were adjusted for rs833061, and rs833061 and rs2146323 were adjusted for rs3025010; and in the recessive model, rs833069, rs3025010, rs2146323, rs7667298, and rs10434 were adjusted for rs833061, and rs833061, rs2146323, rs7667298, and rs10434 were adjusted for rs3025010. values have significance.