Association between Single Nucleotide Polymorphisms in Cardiovascular Developmental Critical Genes and Hypertension: A Propensity Score Matching Analysis

Table 5

The interaction between rs3025010 and SNPs in the CCM3 gene.

Variables	Unadjusted^1		Adjusted^2
	OR (95% CI)	value	OR (95% CI)	value
Additive model
rs3025010 (TT)rs6784267 (CC)	Reference
rs3025010 (CT)rs6784267 (CT)	0.699 (0.416, 1.172)	0.174	0.642 (0.355, 1.160)	0.142
rs3025010 (CC)rs6784267 (CT)	0.162 (0.036, 0.725)	0.017	0.102 (0.018, 0.574)	0.010
rs3025010 (CT)rs6784267 (TT)	1.111 (0.527, 2.342)	0.782	1.086 (0.466, 2.530)	0.849
rs3025010 (CC)rs6784267 (TT)	0.667 (0.111, 3.990)	0.657	0.453 (0.053, 3.843)	0.468
Dominant model
rs3025010 (TT)rs6784267 (CC)	Reference
rs3025010 (CT + CC)
rs6784267 (CT + TT)	0.678 (0.454, 1.013)	0.058	0.574 (0.338, 0.973)	0.039
Recessive model
rs3025010 (CT + TT)
rs6784267 (CT + CC)	Reference
rs3025010 (CC)
rs6784267 (TT)	0.667 (0.111, 3.990)	0.657	1.401 (0.167, 11.763)	0.756

¹OR and values: unadjusted values in univariate analysis. ²OR and values: multivariate analysis. We adjusted age, gender, BMI, smoking, drinking, and physical activity in all three models. Besides, rs833069, rs2146323, rs3212278, rs2305948, and rs7671745 were adjusted in the additive model; rs833061 and rs2146323 were adjusted in the dominant model; and rs833061, rs2146323, rs7667298, and rs10434 were adjusted in the recessive model. values have significance.