Association between rs20456 and rs6930913 of Kinesin-Like Family 6 and Hypertension in a Chinese Cohort
Table 3
Association of KIF6 gene polymorphisms with hypertension susceptibility.
rs no.
Allele or genotype
Cases (n = 382)
Controls (n = 378)
Or (95% CI)
P value
Or (95% CI)
P value
rs20456
T
410 (53.7%)
382 (50.5%)
Ref
Ref
HWE = 0.96
C
354 (46.3%)
374 (49.5%)
0.939 (0.850–1.039)
0.221
0.731 (0.552–0.967)
0.028
TT
118 (30.9%)
88 (23.3%)
Ref
Ref
TC
174 (45.5%)
206 (54.5%)
0.630 (0.495–0.802)
<0.0001
0.416 (0.299–0.578)
<0.0001
CC
90 (23.6%)
84 (22.2%)
0.799 (0.600–1.065)
0.125
0.577 (0.389–0.857)
0.007
Dominant (CC + CT vs. TT)
0.679 (0.540–0.853)
0.001
0.460 (0.338–0.625)
<0.0001
Recessive (CC vs. CT + TT)
1.473 (1.173–1.850)
0.001
1.009 (0.721–1.412)
0.960
rs6930913
C
538 (70.4%)
420 (55.5%)
Ref
Ref
HWE = 0.34
T
226 (29.6%)
336 (44.5%)
0.733 (0.664–0.809)
<0.0001
0.522 (0.386–0.704)
<0.0001
CC
184 (48.6%)
124 (32.8%)
Ref
Ref
CT
170 (44.9%)
172 (45.5%)
0.666 (0.488–0.909)
0.010
0.513 (0.379–0.693)
<0.0001
TT
28 (6.5%)
82 (21.7%)
0.230 (0.142–0.374)
<0.0001
0.325 (0.205–0.515)
<0.0001
Dominant (TT + CT vs. CC)
0.525 (0.392–0.705)
<0.0001
0.460 (0.346–0.610)
<0.0001
Recessive (TT vs. CT + CC)
0.286 (0.181–0.450)
<0.0001
0.454 (0.293–0.704)
<0.0001
Adjusting for gender, age (<65 year, ≥ 65 year), body mass index (normal, overweight), serum level of low-density lipoprotein cholesterol, and creatinine (<88.4 mmol/l, ≥ 88.4 mmol/l). Statistically significant differences () are marked in bold. SNP, single nucleotide polymorphism; HWE, Hardy–Weinberg equilibrium.
