Association between rs20456 and rs6930913 of Kinesin-Like Family 6 and Hypertension in a Chinese Cohort
Table 6
Results of false-positive report probability analysis for the risk associations of rs20456 and rs6930913 polymorphisms to hypertension.
Genotype and variables
Or (95% CI)
P valuea
Statistical powerb
Prior probability
0.25
0.1
0.01
0.001
0.0001
rs20456 T > C
C vs. T
0.731 (0.552–0.967)
0.028
0.741
0.102
0.255
0.790
0.974
1.000
TC vs. TT
0.416 (0.299–0.578)
<0.0001
0.002
0.000
0.001
0.007
0.065
0.411
CC vs. TT
0.577 (0.389–0.857)
0.006
0.237
0.075
0.196
0.729
0.964
0.996
CC/CT vs. TT
0.460 (0.338–0.625)
<0.0001
0.009
0.000
0.001
0.008
0.072
0.437
rs6930913 C > T
T vs. C
0.522 (0.386–0.704)
<0.0001
0.054
0.001
0.003
0.036
0.273
0.790
CT vs. CC
0.513 (0.379–0.693)
<0.0001
0.044
0.001
0.003
0.030
0.237
0.756
TT vs. CC
0.325 (0.205–0.515)
<0.0001
0.001
0.005
0.014
0.132
0.606
0.939
TT/CT vs. CC
0.460 (0.346–0.610)
<0.0001
0.005
<0.0001
<0.0001
0.001
0.014
0.122
TT vs. CT/CC
0.454 (0.293–0.704)
0.001
0.043
0.028
0.080
0.491
0.907
0.990
Haplotype rs20456–rs6930913
CC
1.402 (1.120–1.756)
0.003
0.722
0.013
0.039
0.309
0.819
0.978
CT
0.535 (0.405–0.682)
<0.0001
0.038
<0.0001
<0.0001
0.001
0.012
0.105
TC
1.449 (1.154–1.764)
0.001
0.635
0.001
0.003
0.033
0.257
0.776
TT
0.695 (0.543–0.927)
0.013
0.611
0.061
0.164
0.683
0.956
0.995
CI, confidence interval; OR, odds ratio. aChi-square test was used to calculate the genotype frequency distributions. bStatistical power was calculated using the number of observations in each subgroup and the corresponding ORs and p values in this table. The level of false-positive report probability threshold was set at 0.2, and noteworthy findings are marked in bold.
