Research Article

Relationship between Insulin Secretion and Arterial Stiffness in Essential Hypertension

Table 1

Baseline characteristics of the participants.

VariablesNGT (n = 322)IGT (n = 408)Total (n = 730) value

Age (years)55.2 ± 13.154.5 ± 13.154.8 ± 13.10.448
Female, n (%)147 (45.7)182 (44.6)329 (45.1)0.778
Current smoking, n (%)74 (23)111 (27.2)185 (25.3)0.396
BMI (kg/m2)26.6 ± 3.927.7 ± 4.027.2 ± 4.0<0.001
eGFR (ml min −1 1.73 m2)104.7 ± 20.5106.9 ± 22.6105.9 ± 21.70.174
0 h PG (mmol/L)4.7 ± 0.55.1 ± 0.64.9 ± 0.6<0.001
2 h PG (mmol/L)6.7 ± 0.69.3 ± 0.98.2 ± 1.5<0.001
Δ PG (mmol/L)2.0 ± 0.64.2 ± 1.03.2 ± 1.4<0.001
0 h C-peptide (ng/ml)2.0 (1.7–2.6)2.3 (1.8–2.9)2.2 (1.8–2.7)<0.001
2 h C-peptide (ng/ml)8.0 (6.3–9.9)10.2 (8.5–12.7)9.2 (7.3–11.5)<0.001
Δ C-peptide (ng/ml)5.9 (4.5–7.6)7.7 (6.4–10.2)7.1 (5.4–8.9)<0.001
HbA1c (%)5.9 ± 0.36.0 ± 0.46.0 ± 0.4<0.001
TC (mmol/L)5.1 (4.4–5.8)5.0 (4.3–5.7)5.0 (4.3–5.7)0.420
TG (mmol/L)1.4 (1.0–2.0)1.5 (1.1–2.1)1.5 (1.1–2.1)0.012
HDL-C (mmol/L)1.3 ± 0.41.2 ± 0.31.2 ± 0.3<0.001
LDL-C (mmol/L)2.8 (2.4–3.3)2.8 (2.3–3.3)2.8 (2.3–3.3)0.659
Mean 24h heart rate (beats/min)69.9 ± 8.870.9 ± 9.370.5 ± 9.10.134
Mean 24h SBP (mmHg)169.8 ± 20.2172.0 ± 21.4171.0 ± 20.90.156
Mean 24h DBP (mmHg)107.9 ± 17.0108.5 ± 16.2108.2 ± 16.50.601
baPWV (cm/s)1555.3 (1398.8–1749.0)1556.0 (1371.0–1780.3)1555.8 (1385.8–1762.6)0.884
Stable angina, n (%)47 (14.6)61 (15)108 (14.8)0.893
Calcium channel blocker, n (%)226 (70.2)302 (74.0)528 (72.3)0.250
ACEI, n (%)7 (2.2)13 (3.2)20 (2.7)0.405
ARB, n (%)218 (67.7)271 (66.4)489 (67)0.715
β-Blocker, n (%)132 (41.0)170 (41.7)302 (41.4)0.855
Diuretic, n (%)69 (21.4)83 (20.3)152 (20.8)0.720
α-Blocker, n (%)25 (7.8)29 (7.1)54 (7.4)0.737
Statins use, n (%)199 (61.8)242 (59.3)441 (60.4)0.495

Values are mean ± SD, median (25th and 75th percentiles), or number of patients (percentage of column total). BMI, body mass index; eGFR, estimated glomerular filtration rate; PG, plasma glucose; HbA1c, hemoglobin A1c; TC, total cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein; SBP, systolic blood pressure; DBP, diastolic blood pressure; baPWV, brachial-ankle pulse wave velocity; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin-converting enzyme receptor blocker.