Research Article
The Association between Gly460Trp-Polymorphism of Alpha-Adducin 1 Gene (ADD1) and Arterial Hypertension Development in Ukrainian Population
Table 5
The ADD1 rs4961-polymorphism allelic variants frequency in subjects with different AH risk factors.
| | Risk factors | Genotypes | | G/G, n (%) | G/T, n (%) | T/T, n (%) | G, n (%) | T, n (%) |
| | Males | 43 (93.5) | 3 (6.5) | 0 (0) | 89 (96.7) | 3 (3.3) | | Females | 48 (64.8) | 23 (31.1) | 3 (4.1) | 119 (80.4) | 29 (19.6) | | | Р = 0.002 | Р < 0.001 |
| | BMI < 25 | 51 (87.9) | 7 (12.1) | 0 (0) | 109 (94) | 7 (6) | | BMI ≥ 25 | 40 (64.5) | 19 (30.7) | 3 (4.8) | 99 (79.8) | 25(20.2) | | | Р = 0.008 | Р = 0.001 |
| | Nonsmoker | 74 (74.8) | 22 (22.2) | 3 (3) | 170 (85.9) | 28 (14.1) | | Smoker | 17 (81) | 4 (19) | 0 (0) | 38 (90.5) | 4 (9.5) | | | Р = 0.669 | Р = 0.424 |
| | Salt-resistant | 50 (86.2) | 8 (13.8) | 0 (0) | 108 (93.1) | 8 (6.9) | | Salt-sensitive | 41 (66.2) | 18 (29) | 3 (4.8) | 100 (80.6) | 24 (19.4) | | | Р = 0.022 | Р = 0.005 |
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n: number of cases; BMI: body mass index.
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