International Journal of Hypertension

Research Article

The Association between Gly460Trp-Polymorphism of Alpha-Adducin 1 Gene (ADD1) and Arterial Hypertension Development in Ukrainian Population

Table 6

Association analysis between ADD1 rs4961-polymorphism and arterial hypertension development among individuals of different sexes.


Model of inheritance¹	P_c	OR_c (95% CI)	P_c^int	P_a	OR_a (95% CI)	P_a^int

Dominant	0.559	0.658 (0.161–2.684)	0.125	0.295	0.446 (0.098–2.023)	0.049
	0.061	2.476 (0.961–6.383)		0.045	2.787 (1.022–7.6)

Overdominant	0.734	0.779 (0.185–3.281)	0.269	0.402	0.513 (0.108–2.437)	0.116
	0.137	2.062 (0.794–5.355)		0.105	2.299 (0.839–6.3)

Additive²	0.718	0.767 (0.182–3.233)	0.234	0.388	0.504 (0.106–2.39)	0.095
	0.108	2.19 (0.841–5.704)		0.079	2.483 (0.902–6.839)

P_c: crude value; OR_c: crude odds ratio; P_c^int: crude value interaction terms; P_a: value adjusted for age, BMI, and smoking habit; OR_aodds ratio adjusted for age, BMI, and smoking habit; P_a^int: value interaction terms adjusted for covariates; 95% CI: 95% confidence interval. 1: upper row: results for males; lower row: results for females. 2: upper row: comparison between GT and TT genotypes; lower row: comparison between TT and GG genotypes.