Research Article
Extemporaneous Compounding and Physiological Modeling of Amlodipine/Valsartan Suspension
Table 3
Dissolution of AML and VAL from Valzadepine® tablets and extemporaneous suspension at different pH values and two time points.
| | Tablet | Suspension | | Medium | 15 min | 30 min | 15 min | 30 min |
| | % Dissolved of amlodipine ± (SD) | | pH 1.2 | 84.4 ± (2.14) | 90.3 ± (1.81) (f2 = 51.74) | 85.6 ± (1.32) | 93.3 ± (1.59) | | pH 4.5 | 95.6 ± (1.67) | 98.7 ± (1.73) | 90.4 ± (1.68) | 100.1 ± (1.97) | | pH 6.8 | 87.8 ± (1.97) | 94.3 ± (0.78) | 87.1 ± (0.87) | 89.9 ± (1.05) |
| | % Dissolved of valsartan ± (SD) | | pH 1.2 | 17.7 ± (2.07) | 25.8 ± (1.91) (f2 = 51.80) | 16.1 ± (1.96) | 23.5 ± (1.45) | | pH 4.5 | 49.6 ± (2.18) | 68.1 ± (1.89) (f2 = 51.63) | 44.4 ± (1.84) | 67.9 ± (2.76) | | pH 6.8 | 104.4 ± (1.83) | 103.4 ± (1.22) | 99.8 ± (0.56) | 100.7 ± (1.74) |
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