Research Article
Extemporaneous Compounding and Physiological Modeling of Amlodipine/Valsartan Suspension
Table 5
Observed and predicted pharmacokinetic parameters with percentage of prediction error for both amlodipine and valsartan.
| | | Pharmacokinetic parameter | Cmax (ng/mL) | AUC0-∞ (ng.hr/mL) |
| Amlodipine | Calculated for tablet | 3.030, PE = 5.306% | 169.81, PE = 5.76% | Observed | 3.200 | 160.65 | Calculated for suspension | 3.027, PE = 5.406% | 169.78, PE = 5.74% |
| Valsartan | Calculated for tablet | 704.55, PE = 5.72% | 8517.70, PE = 4,826% | Observed | 747.30 | 8949.70 | Calculated for suspension | 707.22, PE = 5,36% | 8517.60, PE = 4,82% |
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