Extemporaneous Compounding and Physiological Modeling of Amlodipine/Valsartan Suspension

Table 5

Observed and predicted pharmacokinetic parameters with percentage of prediction error for both amlodipine and valsartan.

		Pharmacokinetic parameter
		Cmax (ng/mL)	AUC0-∞ (ng.hr/mL)
Amlodipine	Calculated for tablet	3.030, PE = 5.306%	169.81, PE = 5.76%
	Observed	3.200	160.65
	Calculated for suspension	3.027, PE = 5.406%	169.78, PE = 5.74%
Valsartan	Calculated for tablet	704.55, PE = 5.72%	8517.70, PE = 4,826%
	Observed	747.30	8949.70
	Calculated for suspension	707.22, PE = 5,36%	8517.60, PE = 4,82%