Sex Differences in the Renal Vascular Responses of AT1 and Mas Receptors in Two-Kidney-One-Clip Hypertension
Table 1
The male and female data for body weight before clipping operation (BW1) and 28 days after 2K1C implementation (BW2).
Groups
BW1 (g)
BW2 (g)
RKW (g)/100 gBW
LKW (g)/100 gBW
Male
Sham operated (n = 7)
193 ± 7.2
277 ± 5.8
0 < 0.01
0.37 ± 0.03
0.36 ± 0.01
0.64
Vehicle (n = 9)
192 ± 7.1
272 ± 7.3
0 < 0.0001
0.37 ± 0.01
0.47 ± 0.02
0 < 0.001
Losartan (n = 8)
214 ± 9.2
280 ± 14.5
0 < 0.0001
0.29 ± 0.03
0.46 ± 0.04
0.05
A779 (n = 7)
212 ± 7.1
256 ± 12.9
0.01
0.28 ± 0.04
0.48 ± 0.03
0.02
A779 + losartan (n = 6)
225 ± 8.7
298 ± 7.1
0 < 0.0001
0.31 ± 0.01
0.36 ± 0.02
0.02
Female
Sham operated (n = 8)
151 ± 3.6
195 ± 5.9
0 < 0.0001
0.37 ± 0.02
0.35 ± 0.01
0.37
Vehicle (n = 10)
149 ± 2.1
191 ± 3.7
0 < 0.0001
0.32 ± 0.02
0.42 ± 0.02
0.02
Losartan (n = 7)
152 ± 2.7
182 ± 3.5
0 < 0.0001
0.36 ± 0.02
0.43 ± 0.02
0.05
A779 (n = 9)
145 ± 7.5
187 ± 7.1
0 < 0.0001
0.33 ± 0.01
0.39 ± 0.01
0.02
A779 + losartan (n = 8)
143 ± 2.2
173 ± 3.4
0 < 0.0001
0.27 ± 0.03
0.42 ± 0.03
0.03
The right kidney weight per 100 gram BW (RKWg/100 gBW) and left kidney weight per100 gram BW (LKWg/100 gBW). The data are reported as mean ± standard error of mean. The statistical values were obtained using the paired-sample T-test.
