Sex Differences in the Renal Vascular Responses of AT1 and Mas Receptors in Two-Kidney-One-Clip Hypertension
Table 3
Mean arterial pressure (MAP) in the equilibrium time (base), 30 min after antagonist administration (treat), and graded angiotensin II infusion.
Mean arterial pressure (mmHg)
Antagonists
Angiotensin II (ng/kg/min)
Treatment
Group gender
Base
Treat
30
100
300
1000
Vehicle
Male
120 ± 6.4
121 ± 5.0
124 ± 4.5
129 ± 4.8
134 ± 5.6
150 ± 5.2
Female
114 ± 6.3
112 ± 4.8
113 ± 4.5
116 ± 4.3
120 ± 4.0
135 ± 4.5
Losartan
Male
124 ± 3.3
76 ± 4.7
77 ± 5.4
81 ± 6.3
87 ± 6.5
91 ± 8.2
Female
116 ± 8.6
72 ± 5.7
71 ± 6.4
72 ± 7.4
79 ± 8.9
83 ± 7.0
A779
Male
113 ± 6.6
102 ± 8.1
108 ± 7.7
122 ± 7.3
131 ± 7.1
144 ± 6.3
Female
114 ± 3.5
102 ± 5.4
106 ± 6.1
113 ± 6.0
124 ± 4.4
140 ± 5.1
A779 + losartan
Male
124 ± 6.8
65 ± 2.5
68 ± 2.8
74 ± 3.5
81 ± 5.2
87 ± 3.5
Female
113 ± 6.6
64 ± 6.0
70 ± 4.0
76 ± 4.9
78 ± 6.3
85 ± 5.8
Data are presented as mean ± SEM and were analyzed using repeated-measures ANOVA with the factors group (sex), time (treated with antagonist or dose of Ang II), and their interaction.
