Association between ZFHX3 and PRRX1 Polymorphisms and Atrial Fibrillation Susceptibility from Meta-Analysis

Table 1

Characteristics of studies of ZFHX3 and PRRX1 genes’ two common polymorphisms and atrial fibrillation risk included in our meta-analysis.

Author	Year	Country	Ethnicity	Case	Control	Case			Control			SOC	HWE	Genotype	NOS	AF type
ZFHX3 rs2106261						AA	AG	GG	AA	AG	GG
Okubo	2020	Japan	Asian	289	287	46	143	99	32	109	146	HB	0.096	TaqMan	8	NA
Zaw	2017	Japan	Asian	411	1765	54	182	175	151	725	889	HB	0.853	Illumina	8	NA
Huang	2015	China	Asian	569	1996	99	237	233	216	869	911	PB	0.683	HRM	9	A
Huang	2015	China	Asian	641	1692	103	279	259	197	707	788	PB	0.048	HRM	9	A
Huang	2015	China	Asian	810	1627	128	369	313	149	726	752	PB	0.163	HRM	9	A
Liu	2014	China	Asian	593	996	110	299	184	99	446	451	HB	0.460	MassARRAY	8	Paroxysmal AF
Tomomori	2018	Japan	Asian	362	627	50	181	131	60	250	317	HB	0.298	TaqMan	8	Paroxysmal AF
PRRX1 rs3903239						CC	CT	TT	CC	CT	TT
Kalinderi	2018	Greece	European	167	124	15	62	90	8	49	67	PB	0.809	RCR-RFLP	7	NA
Okubo	2020	Japan	Asian	287	287	29	139	119	59	143	85	HB	0.935	TaqMan	8	NA
Liu	2015	China	Asian	591	996	79	263	249	155	463	378	HB	0.503	MassARRAY	8	Mixed

HB: hospital based; PB: population based; SOC; source of control; PCR-RFLP: polymerase chain reaction followed by restriction fragment length polymorphism; HRM: high-resolution melt; HWE: Hardy–Weinberg equilibrium of the control group; NA: not available; NOS: Newcastle–Ottawa Scale.