Association between ZFHX3 and PRRX1 Polymorphisms and Atrial Fibrillation Susceptibility from Meta-Analysis

Table 2

Stratified analyses of ZFHX3 and PRRX1 genes’ two common polymorphisms on atrial fibrillation risk.

Variables	N	Case/Control	M-allele vs. W-allele	MW vs. WW	MM + MW vs. WW	MM vs. WW	MM vs. MW + WW
ZFHX3 rs2106261			OR(95%CI) PhP I^2	OR(95%CI) PhP I^2	OR(95%CI) PhP I^2	OR(95%CI) PhP I^2	OR(95%CI) PhP I^2
Total	7	3674/8990	1.39(1.31–1.47)0.117 0.000 41.1%	1.37(1.18–1.59)0.007 0.000 66.5%	1.49(1.30–1.70)0.011 0.000 63.6%	1.96(1.73–2.21)0.317 0.000 14.8%	1.70(1.52–1.90)0.643 0.000 0.0%
SOC
HB	4	1654/3675	1.51(1.38–1.64)0.302 0.000 17.7%	1.57(1.38–1.79)0.156 0.000 42.5%	1.68(1.49–1.90)0.151 0.000 43.4%	2.20(1.82–2.66)0.388 0.000 0.7%	1.73(1.45–2.07)0.520 0.000 0.0%
PB	3	2020/5315	1.31(1.21–1.41)0.321 0.000 0.0%	1.17(1.04–1.30)0.584 0.007 0.0%	1.29(1.16–1.43)0.655 0.000 0.0%	1.81(1.54–2.12)0.417 0.000 0.0%	1.68(1.45–1.94)0.384 0.000 0.0%
Genotype
TaqMan	2	650/914	1.55(1.33–1.80) 0.740 0.000 0.0%	1.82(1.46–2.27) 0.668 0.000 0.0%	1.87(1.52–2.30) 0.674 0.000 0.0%	2.06(1.48–2.86) 0.884 0.000 0.0%	1.51(1.11–2.06) 1.000 0.000 0.0%
Other	2	1004/2761	1.47(1.21–1.80)0.068 0.000 70.1%	1.45(1.24–1.70)0.123 0.000 58.1%	1.59(1.19–2.12)0.057 0.002 72.4%	1.47(1.21–1.80)0.095 0.000 64.1%	1.86(1.50–2.32)0.279 0.000 14.5%
HRM	3	2020/5315	1.31(1.21–1.41)0.647 0.000 0.0%	1.17(1.04–1.30)0.584 0.007 0.0%	1.29(1.16–1.43)0.655 0.000 0.0%	1.81(1.54–2.12)0.417 0.000 0.0%	1.68(1.45–1.94)0.384 0.000 0.4%
PRRX1 rs3903239
Total	3	1045/1407	0.82(0.63–1.07)0.023 0.147 73.5%	0.83(0.77–0.99)0.522 0.036 0.0%	0.79(0.67–0.94)0.137 0.006 49.7%	0.68(0.35–1.32)0.011 0.253 78.0%	0.75(0.42–1.31)0.023 0.310 73.5%

P_h: value of the Q-test for the heterogeneity test; P: Z-test for the statistical significance of the OR.