Disturbances of the Gut Microbiota, Sleep Architecture, and mTOR Signaling Pathway in Patients with Severe Obstructive Sleep Apnea-Associated Hypertension

Table 4

KEGG differential genes analysis in severe-OSA with HTN patients compared with non-OSA without hypertension subjects.

Expression	ID	Pathways	Counts	value	Gene ID
Downregulation	hsa04150	mTOR signaling pathway	6	0.006583727	WDR24, DVL1, HRAS, ULK1, STK11, TELO2
	hsa00564	Glycerophospholipid metabolism	4	0.015867516	TAZ, PTDSS2, PNPLA6, DGKZ
	hsa05230	Central carbon metabolism in cancer	3	0.037543817	SIRT6, HRAS, G6PD
	hsa04137	Mitophagy-animal	3	0.040725158	RHOT2, HRAS, ULK1
	hsa05165	Human papillomavirus infection	7	0.052551422	TCIRG1, SCRIB, HDAC10, RFNG, DVL1, HRAS, LAMC3
Upregulation	hsa04727	GABAergic synapse	2	0.013274614	SLC38A2, TRAK2
	hsa03018	RNA degradation	2	0.014053501	SKIV2L2, TTC37
	hsa05332	Graft-versus-host disease	1	0.042416288	KLRC1
	hsa00340	Histidine metabolism	1	0.057882946	CARNMT1
	hsa02010	ABC transporters	1	0.100443008	ABCD2

values < 0.05 were considered significant.