Combination of Oxalobacter Formigenes and Veillonella Parvula in Gastrointestinal Microbiota Related to Bile-Acid Metabolism as a Biomarker for Hypertensive Nephropathy

Figure 1

Comparisons of alpha-diversity and beta-diversity among the groups of H-CKD, hypertension, and healthy control. (a) Rarefaction curves for the mean of Shannon index in the three groups. The curve for each group is nearly smooth when the sequencing data are abundant enough with few new OTUs detected; (b) comparison of diversity in the three groups accessed by the Shannon index. Compared with the control group tested by the Kruskal–Wallis test, the α diversity of H-CKD group and hypertensive groups do not significantly decrease at the genus level; (c) PCoA analysis based on the weighted UniFrac matrix, the two components were 6.1% and 83.4%, respectively; (d) comparison of beta-diversity among the three groups. Overall, the fecal microbiota compositions do not significantly differ among the three groups, while the difference between Hypertension and healthy control is significant; (e) PLS-DA shows significant differences among the three groups; and (f) ROC analysis for the predictive value. The AUC of all the three groups are 1. OTU, operational taxonomic units; PCoA, principal coordinate analysis; PLS-DA, partial least squares discrimination analysis.

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